Hope in the present and the future

[CausticSymmetry]

http://www.sierrasciences.com/splash.html

[Dave228]

Pretty awesome, we were discussing this in Molecular Biology.

[Hairbeback]

Very interesting and informing this topic deserves to be on the top...lol. Anyway I was wondering why they are trying to find chemicals to lengthen the telomeres and was wondering what about maybe a natural herb or something of that nature. I breezed through the tasciences.com website and it said their supplement was a nutracutical what is that exactly?

[CausticSymmetry]

Hairbeback - It's cycloastragenol which comes from astragaloside IV.

There are astragaloside IV products on the market which are much cheaper than TA-65, however
they are not acid processed to convert the astragaloside IV into cycloastragenol.

I found this:

A acid process in methanol where the astragaloside molecule is converted to cycloastragenol - a common ring closing
reaction.

The naturally occuring astragaloside IV molecule is less potent than the cycloastragenol. The patent app above shows the relative potency vis telomerase for all of these molecules, so should be able to expect equal results from the other astragalus extract molecules (dosed equivalently per the patent app relative potency to equal the 5 mg TA-65 dosage effect). Their clinical results should be repeatable for the rest of us using this equivalency as shown in the patent application.

Excerpt from patent: Cycloastragenol is administered at a level of at least 1 mg/day, preferably at least 5 mg/day; or the compound designated herein as astragaloside IV is administered at a level of at least 50 mg/day, preferably at least 100 mg/day."

Example 1. Conversion of astragaloside IV(1) to cycloastragenol(2) To astragaloside IV (1) (5.00 g, mmol) was added"HCl-MeOH 10" (TCI America) (500 mL) and the mixture was stirred at room temperature for 7 days. The reaction mixture was concentrated to about half volume under reduced pressure at 20 C (do not heat). The mixture was
partitioned into aqueous sodium bicarbonate and ethyl acetate.

The aqueous layer was extracted with ethyl acetate again. The organic layers were combined, washed with saturated sodium chloride, dried on anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (20:1-14 : 1 chloroform/methanol). In order to replace the residual solvent with ethanol, the
purified material was dissolved in ethanol and the solvent was removed under reduced pressure to afford 2 (2.1 g, 64%).

[Hairbeback]

I wonder what role who epigenetics have on the gene for producing telomeres in your DNA be?

[CausticSymmetry]

Hairbeback - Offhand, I know that curcumin and carnosine can delay the shortening of telomeres, and apparently so can astragalus.

It may take a drug to lengthening them, but hopefully I'm wrong.

[TK]

Hi CS,

What would an optimal dose of straight astralagus root be, in your opinion?( this IV stuff isnt available in Canada)

thanks!

[CausticSymmetry]

TK - Not sure if the exact, optimal amount of astragalus IV has been determined, however most of the research on Astragalus has been using astragalosides, and apparently, the extract of astragalus, standardized to 0.3% astragalosides is purported to allow optimal therapeutic activity.

Some suggest taking 500 mg of the extract two to three times daily.

[tonyj]

I forgot where I saw the original study, but it appears, for women anyway, that taking multivitamins with anti-oxidants is associated with longer telomeres. Don't know if the same is true for men.

http://www.ajcn.org/cgi/content/abstract/89/6/1857