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Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

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Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  CausticSymmetry on Sun Nov 29, 2015 8:16 am

Sci Adv. 2015 Oct 23;1(9):e1500973. eCollection 2015.
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.
Harel S1, Higgins CA1, Cerise JE1, Dai Z1, Chen JC2, Clynes R1, Christiano AM3.

Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to induce entry into anagen. We show that topical treatment of mouse and human skin with small-molecule inhibitors of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway results in rapid onset of anagen and subsequent hair growth. We show that JAK inhibition regulates the activation of key hair follicle populations such as the hair germ and improves the inductivity of cultured human dermal papilla cells by controlling a molecular signature enriched in intact, fully inductive dermal papillae. Our findings open new avenues for exploration of JAK-STAT inhibition for promotion of hair growth and highlight the role of this pathway in regulating the activation of hair follicle stem cells.

Note: Pharmacologic (not necessary), better to resolve the underlying issue..and when in doubt, use a nutraceutical that modulates the activity.

I've been using this for quite a while to do that very thing. It's also anti-cancer, pro-liver too.

http://www.iherb.com/Dragon-Herbs-Standardized-Scute-500-mg-Each-100-Veggie-Caps/55598

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  Kazbar on Tue Dec 01, 2015 12:02 am

CS does this supplement you suggested put resting hairs in an Anagen phase?

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  CausticSymmetry on Tue Dec 01, 2015 3:33 am

Kazbar wrote:CS does this supplement you suggested put resting hairs in an Anagen phase?

Yes, exactly. It stimulates an earlier conversion from telogen (resting) to anagen (growth).

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  cdto2012 on Tue Dec 01, 2015 5:31 am

Thanks for sharing about such a useful herb. There are like 350 varieties of the plant, but I guess it is the root of this plant.
SCUTELLARIA BAICALENSIS ROOT EXTRACT - link also includes studies

http://rg-cell.com/scutellaria-baicalensis-root-extract/

Not too expensive, anti cancer, anti aging, inti inflammatory; looks like a winner.

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  hairyshowers on Tue Dec 01, 2015 5:55 am

Mines arriving in a few days, perfec, thanks for the info CS
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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  Kazbar on Tue Dec 01, 2015 5:36 pm

CS found this one on iherb it has around 99 reviews seems like a good supplement particularly for liver detox ...what do you think?

http://au.iherb.com/Now-Foods-Liver-Detoxifier-Regenerator-180-Capsules/11016

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  MikeGore on Wed Dec 09, 2015 1:10 am

Is this the same pathway that drugs like Setipiprant/Sulpha work with regulating the immune system that affects the hair follicle?

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

Post  MovieJunkie89 on Wed Dec 09, 2015 3:37 am

Do you know if this does anything for PGE2/PGD2?

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Re: Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

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