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Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.

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Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.

Post  CausticSymmetry on Thu Dec 10, 2015 12:32 pm

Biol Pharm Bull. 2015;38(12):1856-63. doi: 10.1248/bpb.b15-00387.
Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.
Choi JS1, Park JB, Moon WS, Moon JN, Son SW, Kim MR.

We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope(). Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.

Full Study:

https://www.jstage.jst.go.jp/article/bpb/38/12/38_b15-00387/_pdf

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Re: Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.

Post  cdto2012 on Thu Dec 10, 2015 2:59 pm

I find super critical methods very interesting and did a bit of checking up on rice bran oil. It seems that the active ingredient is gamma-oryzanols (γ-oryzanols) . Also there is

"Tocotrienols (TRF) have high antioxidant properties and are becoming more noteworthy in scientific research"
from a useful article about this rice bran oil, I know some of the guys are into the effects of oils, and the link talks about the omega 3 to omega 6 imbalance in this oil for eating.

http://preventdisease.com/news/13/021113_Rice-Bran-Oil-One-Big-Health-Disadvantage-Outweighs-All-Its-Advantages.shtml

I found a source for the oil, but I doubt it is super-critical extract. The problem is that solvents like hexane and high heat can be used in cheap extracts. The specs for the super critical extraction are available online, and are in normal ranges. I know how to make this product. I guess with more research we could find prices and sources.

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