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Supplemental or Herbal Potassium Channel Openers?

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Supplemental or Herbal Potassium Channel Openers?

Post  Changexpert on Mon Dec 21, 2015 5:21 am

Are there any supplements or herbs that open potassium channel? Medical grade ones are easy to find on Google, the most popular one being minoxidil.
I am just curious if there is an alternative to minox since minox decreases collagen level in the long-term.
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Re: Supplemental or Herbal Potassium Channel Openers?

Post  CausticSymmetry on Mon Dec 21, 2015 6:03 am

Changexpert wrote:Are there any supplements or herbs that open potassium channel? Medical grade ones are easy to find on Google, the most popular one being minoxidil.
I am just curious if there is an alternative to minox since minox decreases collagen level in the long-term.

Minoxidil in my opinion is never worth the risk, plus there are other topicals that are better without sides.

That said, a derivative of stevia is a potassium channel opener.

Planta Med. 2004 Feb;70(2):108-12.

Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells.

Isosteviol is a derivative of stevioside, a constituent of Stevia rebaudiana, and is commonly used as a non-caloric sugar substitute in Japan and Brazil. The present study attempted to elucidate the role of potassium (K (+)) channels in the action of isosteviol on intracellular calcium concentrations ([Ca (2+)]i) in cultured vascular smooth muscle (A7r5) cells using the Ca (2+)-sensitive dye Fura-2 as an indicator. The increase of [Ca (2+)]i in A7r5 cells produced by vasopressin (1 micromol/L) or phenylephrine (1 micromol/L) was attenuated by isosteviol from 0.01 micromol/L to 10 micromol/L. The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca (2+)]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca (2+)]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present. Therefore, not only did the ATP-sensitive potassium (K (ATP)) channel affect the action of isosteviol on [Ca (2+)]i modulation in A7r5 cells, but also those on the small conductance calcium-activated potassium (SK (Ca)) channels and voltage-gated (Kv) channels. However, the blockers of large-conductance Ca (2+)-activated potassium channels failed to modify the inhibitory action of isosteviol on [Ca (2+)]i. The obtained results indicated that a decrease of [Ca (2+)]i in A7r5 cells by isosteviol is mainly mediated by the selective opening of K (ATP) channel or/and SK (Ca) channel. Alteration in the Kv channel also plays a critical role in the inhibitory action of isosteviol.

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Re: Supplemental or Herbal Potassium Channel Openers?

Post  Changexpert on Mon Dec 21, 2015 6:17 am

How is Isosteviol derived from stevia? I am assuming using stevia would not produce the same result as I have never heard of anybody trying stevia for hair loss...

Also, what are topicals that works better than minox?
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Re: Supplemental or Herbal Potassium Channel Openers?

Post  magic_gro on Mon Dec 21, 2015 7:17 am

Minoxidil might work as a growth stimulator because of other mechanisms, namely because it increases the PGE2 production.
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Re: Supplemental or Herbal Potassium Channel Openers?

Post  Changexpert on Mon Dec 21, 2015 2:07 pm

magic_gro wrote:Minoxidil might work as a growth stimulator because of other mechanisms, namely because it increases the PGE2 production.
Yes, I was just referring to potassium channel opening effect of minox. I think potassium channel opening is a key to decalcification, giving a good scalp foundation for hair to grow and proliferate.
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