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Dose-dependent valproate induced alopecia in patients with mental disorders.

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Dose-dependent valproate induced alopecia in patients with mental disorders.

Post  CausticSymmetry on Fri Jan 08, 2016 4:15 am

Indian J Pharmacol. 2015 Nov-Dec;47(6):690-2. doi: 10.4103/0253-7613.169587.
Dose-dependent valproate-induced alopecia in patients with mental disorders.
Tomita T1, Goto H1, Yoshida T2, Tanaka K3, Sumiya K4, Kohda Y5.

Drug-induced hair loss may occur as a side effect in patients treated with valproate. However, few studies have reported a relationship between the blood levels of valproate and the occurrence of hair loss. We report three cases of alopecia that occurred in patients who received sodium valproate for mental disorders. In all three cases, alopecia appeared after long-term valproate exposure with a plasma concentration of 100 µg/ml approximately. However, the alopecia resolved in all cases after dose reduction or treatment discontinuation. Therefore, alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate. Based on these findings, we believe that patients with high plasma concentrations of valproate should be closely monitored for the occurrence of side effects, particularly alopecia.

Also known as Depakote, Depakene, Stavzor, and Valproic acid.

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