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Ricinoleic acid - PTGDS inhibitor!

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Ricinoleic acid - PTGDS inhibitor!

Post  ninjishal on Mon Jan 18, 2016 8:07 am

Ricinoleic acid is a strong PTGDS inhibitor. It was one of the 5 strongest plant constituents that inhibits PTGDS between 389 constituents studied. Another big plus for it! It's not only an exogenous PGE2 agonist but it also must lower PGD2. Great!

http://www.ncbi.nlm.nih.gov/pubmed/26456343 - last month study!!

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss.
Fong P1, Tong HH2, Ng KH2, Lao CK2, Chong CI2, Chao CM2.
Author information
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Many herbal topical formulations have been marketed worldwide to prevent hair loss or promote hair growth. Certain in vivo studies have shown promising results among them; however, the effectiveness of their bioactive constituents remains unknown.
AIM OF THE STUDY:
Recently, prostaglandin D2 (PGD2) inhibition has been discovered as a pharmacological mechanism for treating androgenic alopecia (AGA). This present study was aimed to identify prostaglandin D2 synthase (PTGDS) inhibitors in traditional Chinese medicines (TCMs) for treating AGA.
MATERIALS AND METHODS:
In this study, 389 constituents of 12 selected herbs were docked into 6 different crystal structures of PTGDS. The accuracy of the docking methods was successfully validated with experimental data from the ZINC In Man (Zim) database using receiver operating characteristic (ROC) studies. Seven essential drug properties were predicted for topical formulation: skin permeability, sensitisation, irritation, corrosion, mutagenicity, tumorigenicity and reproductive effects.
RESULTS:
Many constituents of the twelve herbs were found to have more advanced binding energies than the experimentally proved PTGDS inhibitors, but many of them were indicative of at least one type of skin adverse reactions, and exhibited poor skin permeability.
CONCLUSIONS:
Overall, ricinoleic acid, acteoside, amentoflavone, quercetin-3-O-rutinoside and hinokiflavone were predicted to be PTGDS inhibitors with good pharmacokinetic properties and minimal adverse skin reactions. These compounds have the highest potential for further in vitro and in vivo investigation with the aim of developing safe and high-efficacy hair loss treatment.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
KEYWORDS:
Androgenic alopecia; Docking; Hair loss; Prostaglandin D2 synthase; Traditional Chinese medicines

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  CF on Mon Jan 18, 2016 12:33 pm

Thanks, ninjishal!

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  Hairbeback on Mon Jan 18, 2016 1:03 pm

Is this found in any foods or just castor oil? I have a fear of using castor oil

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  CausticSymmetry on Mon Jan 18, 2016 2:32 pm

Hairbeback wrote:Is this found in any foods or just castor oil? I have a fear of using castor oil

It is found has an added substance in this product, which I do take for hair, as the ingredients also promote the inhibition of prostaglandin (PGD2)


http://goo.gl/TNDESu

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  Faither on Wed Jan 20, 2016 7:25 am

i've always thought that onion juice is a good topical

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  bov51 on Wed Jan 20, 2016 11:56 am

Thats good to know, anyone know where we can get straight pure Ricinoleic acid. Ricinoleic acid only weight 298.461 g/mol compare to castor oil that weights more than 500. We don't even need dmso.

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Re: Ricinoleic acid - PTGDS inhibitor!

Post  Faither on Thu Jan 21, 2016 9:09 pm

That study claims Swisstemple theory and some other guys stories who had succes with castor oil. Now how about the rest? For example capers are very high in quercetin 3-O-rutinozide, do you think caper juice as topical could work?

http://phenol-explorer.eu/contents/polyphenol/296

Or for example Styphnolobium japonicum - the plant from the rutin is derived - extreme rutin content.

I know we could just put pure rutin or ricinoleic acid on head, however i've always thought that there's some special synergy in components of whole plants..

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