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Topical Estrogen for HairLoss

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Topical Estrogen for HairLoss

Post  Resistance on Mon Feb 29, 2016 8:02 am

Hi Guys,

Looking for everyone's views on a topic that I haven't seen discussed properly yet.

Here's the question, is topical estrogen good, neutral or bad for hair loss?

The idea: Estrogen can bind to androgen receptors and AR and thus this occupancy means a decrease in DHT (I am talking about DHT at scalp levels). A similiar concept to Cyproterone acetate and others anti androgens that bind to DHT receptors and keep these occupied.

PS: I wish I could post links, but as a new member I don't have that permission, if you're interested just copy paste the info I provide below on google and you should reach its source.

Source 1
"Equilibrium binding studies indicated that the observed decrease in [3H]DHT binding after estradiol treatment was due to an absolute decrease in the number of cytoplasmic androgen receptors per cell. The estradiol-mediated reduction in androgen receptor content was dose dependent; a 50% reduction in androgen receptor number was observed after 6 days of treatment with 2.6 X 10(-11) M estradiol. Additional experiments revealed that MCF-7 cells exhibited a time-dependent increase in androgen receptor content when estradiol was withdrawn; continued estradiol treatment prevented this rise in receptor content. Moreover, androgen receptor levels began to decrease from the point when the ethanol vehicle added to the medium was replaced with 2.6 nM estradiol. In summary, estradiol treatment caused a reduction in androgen receptors, and estradiol withdrawal lead to a rise in androgen receptors"

Source 2
"In Europe, topically applied estrogens such as 17B-estadiole are used to treat androgenetic alopecia, both in women and men. The femal hormone 17B-Estradiol can be used only in women, whereas the hormonally almost inactive isomer 17a-estradiol can be used in men as well. "

Source 3
Page 5529 treats E2 as being 17β-estradiol, a estrogen hormone and claims:

"The competitive binding curve in Fig. 3B further showed that unlabeled E2, T, and DHT, but not Dex, can compete well with [3H]E2 binding to AR, indicating E2 specific binding between E2 and AR. The fact that unlabeled E2 can compete better than T And there's a graph for the ones that want to look into it.

Source 4
"systemic estrogens increase production of the glycoprotein sex hormone-binding globulin (SHBG), leading to a decrease in free testosterone. A 6 month study of a topical 17α-estradiol 0.025% preparation applied by 7 women with FPHL reported stabilization of hair loss and/or increased telogen hair shedding compared to 2 female control subjects.[25] More studies are warranted to validate the use of topical estrogens in AGA

Resistance

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Re: Topical Estrogen for HairLoss

Post  shaftless on Mon Feb 29, 2016 11:35 am

The topical estradiol they used in europe...do you need a prescription for it? Or is it overthecounter. Why isn't it available here in north america?

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Re: Topical Estrogen for HairLoss

Post  SonofOdin on Mon Feb 29, 2016 2:55 pm

Would this be similar to the people rubbing estrogenic essential oils on themselves?(peppermint oil, tea tree oil etc.)
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Re: Topical Estrogen for HairLoss

Post  Resistance on Tue Mar 01, 2016 6:41 am

I don't know if you need to use a prescription for estradiol but you can get estrogen under several forms, you can buy this pueraria murifica (if i spelt that right) which mimics estrogen and is used by women to increase their breast and other femenine parts... you can get that anywhere and that is really strong estrogen.

So yea, I was wondering what people around here think about the logic of this subject... could it work as part of someones routine?

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Re: Topical Estrogen for HairLoss

Post  sanderson on Sun Mar 06, 2016 7:29 am

check out diane35.. for RESEARCH PURPOSES.. i think people were using it topically. although i know it contains other stuff besides estradiol. although.. this shit is dangerous.. you could start becoming a woman.. i would stay away FOR SURE.
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Re: Topical Estrogen for HairLoss

Post  Resistance on Sun Mar 06, 2016 9:55 am

sanderson wrote:check out diane35.. for RESEARCH PURPOSES.. i think people were using it topically. although i know it contains other stuff besides estradiol. although.. this shit is dangerous.. you could start becoming a woman.. i would stay away FOR SURE.

I don't think you will become a woman by using a topical, that itself does not make any sense. Yes the estrogen will affect the applied area but I very much doubt it will run in your bloodstream and affects all your other parts but regardless it will be interesting to see whoever has tried this. Myself I want to stay away of all sorts of estrogen

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Re: Topical Estrogen for HairLoss

Post  Mxssingno on Mon Nov 27, 2017 10:44 pm

Another good thread on this: immortalhair.forumandco.com/t8249-is-raising-estrogen-in-the-scalp-a-bad-idea

On another forum a user was claiming success with topical estradiol, but they quit due to the side effects. After reading about people developing resistance to 5AR inhibitors, I still wonder if this would be a better long-term way to oppose the DHT.

If something could boost aromatase locally using topical application would be ideal, but I can't find anything. Pueraria mirifica contains phytoestrogens that are supposed to act similarly to estradiol, so I'm going to try it topically. Considering a 0.25mm microneedle also to enhance absorption in problem areas.

If it does go systemic I'm hoping it will be possible to flush it out with something that alters estrogen metabolism. Based on some how some women develop MPB from using aromatase inhibitors I don't think I want to touch those.

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Re: Topical Estrogen for HairLoss

Post  long hair on Tue Nov 28, 2017 10:50 pm

i was reading this thread for long time ,the guy use topical estrogen -alpicort F ,and it gave hem a great result but after few months he ended with Fin simi side effect and he start to get gyno so he shut his treatment off ..if you want you can try phytoestrogen  as topical and give your result here, idk if it good or bad idea but through trial and error we gather information . remember that sage using plant that may contain phytoestrogen.
https://www.hairlosstalk.com/interact/threads/whatevrs-success-story-with-timeline.101353/
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Re: Topical Estrogen for HairLoss

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