Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.

View previous topic View next topic Go down

Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.

Post  CausticSymmetry on Sat Mar 05, 2016 2:27 am

Science. 2016 Feb 5;351(6273):613-7. doi: 10.1126/science.aad5440.
Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
Wang L1, Siegenthaler JA2, Dowell RD3, Yi R4.

Stem cell quiescence preserves the cell reservoir by minimizing cell division over extended periods of time. Self-renewal of quiescent stem cells (SCs) requires the reentry into the cell cycle. In this study, we show that murine hair follicle SCs induce the Foxc1 transcription factor when activated. Deleting Foxc1 in activated, but not quiescent, SCs causes failure of the cells to reestablish quiescence and allows premature activation. Deleting Foxc1 in the SC niche of gene-targeted mice leads to loss of the old hair without impairing quiescence. In self-renewing SCs, Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity.

Further information:

http://www.pnas.org/content/early/2016/02/23/1601569113.full.pdf

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 11905
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum