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Emodin downregulates Androgen Receptors

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Emodin downregulates Androgen Receptors

Post  SuperMechanioventraliosis on Sun May 08, 2016 5:03 am

http://cancerres.aacrjournals.org/content/65/6/2287.long

I have started adding Cascara Sagrada topically.




It is recommended by Ray Peat for bowel movement, but it can't be bad to downregulate Androgen receptors. The article claims emodin can deplete AR in cells, despite cells having androgen stimulation.

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Re: Emodin downregulates Androgen Receptors

Post  Biffy on Mon May 09, 2016 12:11 am

It seems that we need to take 50% Resveratrol, as it contains large amounts of Emodin! Very Happy. Some people get terrible diarrhea from 50% Resveratrol, but I don't get that - I use MRM Resveratrol with Grape Seed Extract.

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Re: Emodin downregulates Androgen Receptors

Post  CF on Mon May 09, 2016 1:37 am

FWIW, emodin is a tyrosinase inhibitor.

https://www.ncbi.nlm.nih.gov/pubmed/18338768


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Re: Emodin downregulates Androgen Receptors

Post  SuperMechanioventraliosis on Mon May 09, 2016 9:19 am

Thank you CF.

From what I'm understanding, tyrosinase is the rate limiting factor in melanin production. Melanin concentration depends on follicle stage, but tyrosinase is higher towards end of anagen phase. But not sure how it's involved in early anagen/transition.

https://bradscholars.brad.ac.uk/bitstream/handle/10454/5324/P.%20Davies%20full%20phd.pdf?sequence=1
This study found that early greying protects againts hair loss, and they conclude it is the lessend ROS and oxidative stress relief from melanin production.

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Re: Emodin downregulates Androgen Receptors

Post  CF on Mon May 09, 2016 11:28 am

No problem, Super.  I just posted it because I wouldn't want to apply a tyrosinase inhibitor to my head for fear of it turning my hair grey.

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Re: Emodin downregulates Androgen Receptors

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