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Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

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Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  CausticSymmetry on Mon Oct 24, 2016 2:04 pm

Ann Dermatol. 2016 Oct;28(5):586-592. Epub 2016 Sep 30.
Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.
Kim YS1, Jeong KH1, Kim JE1, Woo YJ1, Kim BJ2, Kang H1.

BACKGROUND:
Microneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding.
OBJECTIVE:
The aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model.
METHODS:
A disk microneedle roller was applied to each group of mice five times a week for three weeks. First, to identify the optimal length and cycle, microneedles of lengths of 0.15 mm, 0.25 mm, 0.5 mm, and 1 mm and cycles of 3, 6, 10, and 13 cycles were applied. Second, the effect of hair growth and hair-growth-related genes such as Wnt3a, β-catenin, vascular endothelial growth factor (VEGF), and Wnt10b was observed using optimized microneedle. Outcomes were observed using visual inspection, real-time polymerase chain reaction, and immunohistochemistry.
RESULTS:
We found that the optimal length and cycle of microneedle treatment on hair growth was 0.25 mm/10 cycles and 0.5 mm/10 cycles. Repeated microneedle stimulation promoted hair growth, and it also induced the enhanced expression of Wnt3a, β-catenin, VEGF, and Wnt10b.
CONCLUSION:
Our study provides evidence that microneedle stimulation can induce hair growth via activation of the Wnt/β-catenin pathway and VEGF. Combined with the drug delivery effect, we believe that microneedle stimulation could lead to new approaches for alopecia.
KEYWORDS:
Alopecia; Hair; Hair follicle; Microneedle

Full study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064188/

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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  johndoe1225 on Mon Oct 24, 2016 2:34 pm

Wow, that's pretty amazing!

But I don't quite understand the terms they use, so basically, 0.25mm and 0.5mm are best?  So something like a dermaroller (or dermapen type thing) would be good?

And what do they mean by "cycles"?  Does "10 cycles" mean just going over the same area 10 times?

EDIT: After reading the full story it seems that yes, a "cycle" is just one full sweep on the area

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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  CausticSymmetry on Tue Oct 25, 2016 2:51 am

There are earlier studies on this using humans and it significantly improves whatever topical one is using.

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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  johndoe1225 on Tue Oct 25, 2016 4:14 am

CausticSymmetry wrote:There are earlier studies on this using humans and it significantly improves whatever topical one is using.

Ok thanks, I will definitely buy either a .25 or .5mm DR, and I just started a new topical with ginger so this will be a nice experiment

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RE: CS

Post  CampOfDavid on Tue Oct 25, 2016 4:55 am

Do you think Zix is a good and safe topical to use with the DR?
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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  CausticSymmetry on Tue Oct 25, 2016 12:37 pm

CampOfDavid wrote:Do you think Zix is a good and safe topical to use with the DR?

It should help.

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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

Post  long hair on Tue Oct 25, 2016 6:45 pm

CausticSymmetry wrote:There are earlier studies on this using humans and it significantly improves whatever topical one is using.

yea some user in HLT claim he have a good result using green tea extract (EGCG) before dermaroller .
dermaroller also suppose to help with accumulated sebum and calcification under scalp and of curse it renew scalp tissue.
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Re: Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model.

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