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Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.

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Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.

Post  CausticSymmetry on Wed Nov 16, 2016 1:04 pm

Genes Dev. 2016 Nov 2. [Epub ahead of print]
Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.
Zhang B1,2, Tsai PC1,2, Gonzalez-Celeiro M1,2,3, Chung O1,2, Boumard B1,2, Perdigoto CN4,5, Ezhkova E4,5, Hsu YC1,2.

Growth and regeneration of one tissue within an organ compels accommodative changes in the surrounding tissues. However, the molecular nature and operating logic governing these concurrent changes remain poorly defined. The dermal adipose layer expands concomitantly with hair follicle downgrowth, providing a paradigm for studying coordinated changes of surrounding lineages with a regenerating tissue. Here, we discover that hair follicle transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog (SHH). Depletion of Shh from HF-TACs abrogates both dermal adipogenesis and hair follicle growth. Using cell type-specific deletion of Smo, a gene required in SHH-receiving cells, we found that SHH does not act on hair follicles, adipocytes, endothelial cells, and hematopoietic cells for adipogenesis. Instead, SHH acts directly on adipocyte precursors, promoting their proliferation and their expression of a key adipogenic gene, peroxisome proliferator-activated receptor γ (Pparg), to induce dermal adipogenesis. Our study therefore uncovers a critical role for TACs in orchestrating the generation of both their own progeny and a neighboring lineage to achieve concomitant tissue production across lineages.

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