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Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

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Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Post  CausticSymmetry on Sun Dec 11, 2016 5:16 am

Development. 2013 Apr 15; 140( 8 ): 16761683.
doi: 10.1242/dev.090662
Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Although the hair shaft is derived from the progeny of keratinocyte stem cells in the follicular epithelium, the growth and differentiation of follicular keratinocytes is guided by a specialized mesenchymal population, the dermal papilla (DP), that is embedded in the hair bulb. Here we show that the number of DP cells in the follicle correlates with the size and shape of the hair produced in the mouse pelage. The same stem cell pool gives rise to hairs of different sizes or types in successive hair cycles, and this shift is accompanied by a corresponding change in DP cell number. Using a mouse model that allows selective ablation of DP cells in vivo, we show that DP cell number dictates the size and shape of the hair. Furthermore, we confirm the hypothesis that the DP plays a crucial role in activating stem cells to initiate the formation of a new hair shaft. When DP cell number falls below a critical threshold, hair follicles with a normal keratinocyte compartment fail to generate new hairs. However, neighbouring follicles with a few more DP cells can re-enter the growth phase, and those that do exploit an intrinsic mechanism to restore both DP cell number and normal hair growth. These results demonstrate that the mesenchymal niche directs stem and progenitor cell behaviour to initiate regeneration and specify hair morphology. Degeneration of the DP population in mice leads to the types of hair thinning and loss observed during human aging, and the results reported here suggest novel approaches to reversing hair loss.

Full study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621486/

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Re: Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Post  johndoe1225 on Sun Dec 11, 2016 7:30 am

This part is especially interesting:

"This suggests that therapeutic interventions in humans that cause only a minor direct improvement in DP cell number may be sufficient to restore hair cycling and harness the natural regenerative ability of the follicle for further progress towards robust hair growth."


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Re: Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Post  blue88 on Mon Dec 12, 2016 9:09 am

CS - what are the best ways to stop degeneration of the DP?

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Re: Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

Post  CausticSymmetry on Tue Dec 13, 2016 3:31 am

blue88 wrote:CS - what are the best ways to stop degeneration of the DP?

Most of what I take supports the health of the dermal papilla (including promoting growth, elongation and down regulating TGF-beta, MMP-9, and dozens of others.

Because there are individual variances as well on an epigenetic level (which is modifiable), mineral balancing plays a vital role in endocrine function.




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Re: Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

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