Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
» Holism verse reductonism
Thu Jan 18, 2018 5:14 pm by Hairbeback

» Detumescence Reloaded
Thu Jan 18, 2018 4:50 am by Hairbeback

» Are these tiny hairs regrowth or normal?
Mon Jan 15, 2018 8:40 am by Hunter77

» Since you guy think Peer Reviews are infallible
Sun Jan 14, 2018 5:57 pm by Hairbeback

» Why Curcumin 95?
Fri Jan 12, 2018 10:22 am by Balthier

» Immortal hair vets from '09 to '11 check in.
Fri Jan 12, 2018 9:53 am by Balthier

» An interesting new update on Ortho Nutrition Ecklonia Cava (now 300% higher Polyphenol content)
Thu Jan 11, 2018 8:11 am by CausticSymmetry

» Tocotrienol - Libido Boost
Wed Jan 10, 2018 4:26 am by CausticSymmetry

» Henry Choys detumescence therapy.
Tue Jan 09, 2018 8:28 pm by Oker

Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet.

View previous topic View next topic Go down

Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet.

Post  CausticSymmetry on Mon Jan 23, 2017 4:17 pm

Molecules. 2017 Jan 14;22(1). pii: E132. doi: 10.3390/molecules22010132.
Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet.
Taira N1, Nguyen BC2,3, Tawata S4.

PAK1 (p21-activated kinase 1) is an emerging target for the treatment of hair loss (alopecia) and cancer; therefore, the search for PAK1 blockers to treat these PAK1-dependent disorders has received much attention. In this study, we evaluated the anti-alopecia and anticancer effects of PAK1 inhibitors isolated from Alpinia zerumbet (alpinia) in cell culture. The bioactive compounds isolated from alpinia were found to markedly promote hair cell growth. Kaempferol-3-O-β-d-glucuronide (KOG) and labdadiene, two of the isolated compounds, increased the proliferation of human follicle dermal papilla cells by approximately 117%-180% and 132%-226%, respectively, at 10-100 μM. MTD (2,5-bis(1E,3E,5E)-6-methoxyhexa-1,3,5-trien-1-yl)-2,5-dihydrofuran) and TMOQ ((E)-2,2,3,3-tetramethyl-8-methylene-7-(oct-6-en-1-yl)octahydro-1H-quinolizine) showed growth-promoting activity around 164% and 139% at 10 μM, respectively. The hair cell proliferation induced by these compounds was significantly higher than that of minoxidil, a commercially available treatment for hair loss. Furthermore, the isolated compounds from alpinia exhibited anticancer activity against A549 lung cancer cells with IC50 in the range of 67-99 μM. Regarding the mechanism underlying their action, we hypothesized that the anti-alopecia and anticancer activities of these compounds could be attributed to the inhibition of the oncogenic/aging kinase PAK1.
KEYWORDS:
d-glucuronide, Alpinia zerumbet, PAK1 inhibitors, cancer, hair growth, kaempferol-3-O-β-

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 11978
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet.

Post  blue88 on Tue Jan 24, 2017 8:16 am

Hey CS, do you have a link to a supplement that would provide this compound?

blue88

Posts : 18
Join date : 2015-10-10

View user profile

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum