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Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

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Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

Post  CausticSymmetry on Tue Feb 07, 2017 9:47 am

Exp Dermatol. 2017 Feb 3. doi: 10.1111/exd.13308. [Epub ahead of print]
Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.
Kwack MH1, Lee JH1, Seo CH1, Kim JC1, Kim MK1, Sung YK1.

The stress-related neurohormones including glucocorticoids (GCs) are secreted by hair follicles (HFs) and GCs suppress murine hair growth in vivo. In this study, we found that dexamethasone (Dex), a synthetic GC, increased the expression of dickkopf-1 (DKK1), a known catagen inducer, in dermal papilla (DP) cells but not in follicular keratinocytes. The neutralizing DKK1 antibody significantly attenuated the Dex-induced inhibition of human hair shaft elongation. In addition, the neutralizing Dkk1 antibody delayed Dex-induced catagen in mice. Collectively, our data strongly suggest that stress-related neurohormones cause DP cells to secrete DKK1, thereby leading to stress-associated disturbances in hair growth.

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Re: Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

Post  johndoe1225 on Tue Feb 07, 2017 9:59 am

Hi

Thanks for the article

Here's some more interesting information on DKK-1:

https://www.ncbi.nlm.nih.gov/pubmed/20701628

Apparently LAA supresses it

I can't really tell though, was this study using a topical?  It sounds like it.

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Re: Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

Post  CausticSymmetry on Tue Feb 07, 2017 1:56 pm

Yes, I am familiar with this study. However, a type of sulfur was necessary for it to work.

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Re: Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

Post  cdto2012 on Tue Feb 07, 2017 4:22 pm

Dickkopf-1  sounds like a side effect,  not the smartest name to choose  jocolor

"glucocorticoids (GCs) are secreted by hair follicles (HFs) and GCs suppress murine hair growth in vivo "

interesting that GCs is an anti inflammatory,  but seems to suppress hair growth.  Since they are related to glucose processing,  I wonder if metformin could help regulate the GCs , since it is used for anti aging and glucose regulation.

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Re: Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

Post  johndoe1225 on Wed Feb 08, 2017 3:48 am

cdto2012 wrote:Dickkopf-1  sounds like a side effect,  not the smartest name to choose  jocolor

"glucocorticoids (GCs) are secreted by hair follicles (HFs) and GCs suppress murine hair growth in vivo "

interesting that GCs is an anti inflammatory,  but seems to suppress hair growth.  Since they are related to glucose processing,  I wonder if metformin could help regulate the GCs , since it is used for anti aging and glucose regulation.

Hahaha Very Happy

About Sage's topical, I just tried it for the first time today.  I'm pretty sure this is wrong and it's too diluted, but I used two cups of distilled water, a bunch of cilantro, some rosemary, and a green tea bag, and just put them all in a pot (I didn't heat it), put a cover on and let it sit for a few hours.  I guess next time I'll just use 1 cup and the same amount of herbs. Maybe mixing it in a blender would help too.

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Re: Dickkopf-1 is involved in dexamethasone-mediated hair follicle regression.

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