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Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

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Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  CausticSymmetry on Mon Mar 13, 2017 11:28 am

Clin Cosmet Investig Dermatol. 2017 Feb 27;10:71-85. doi: 10.2147/CCID.S123401. eCollection 2017.
Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Burg D1, Yamamoto M2, Namekata M2, Haklani J1, Koike K2, Halasz M1.

BACKGROUND:
There are very few effective, scientifically validated treatments with known mechanisms of action for treatment of hair loss in both men and women. Fibroblast growth factor 5 (FGF5) is an important factor in the irreversible transition from anagen to catagen, and inhibition of FGF5 prolongs anagen phase and reduces hair loss.
OBJECTIVE:
We aimed to screen botanically derived molecules for FGF5 inhibitory activity in vitro and assess efficacy in a clinical setting.
METHODS:
We screened for FGF5 inhibitory efficacy via a novel 2-step in vitro pipeline consisting of an engineered FGF5 responsive cell line, followed by an activated dermal papillae (DP) cell method. Efficacy in a clinical setting was assessed in a randomized, single-blind, placebo-controlled trial against early- to mid-stage pattern hair loss in men and women.
RESULTS:
We observed FGF5 inhibitory activity for a number of compounds from the monoterpenoid family, many showing greater inhibitory efficacy than our previously reported crude plant extracts. Evaluation of a lead candidate in a clinical study over 112 days showed a significant improvement in anagen:telogen (AT) ratio (p = 0.002), reduced hair fall (p = 0.007) and improved visual grading (p = 0.004). Scientifically matched photography on a subgroup of randomly chosen participants highlighted significant improvement in hair density, with increases evident in all tested participants compared to baseline.
CONCLUSION:
Isolates from the monoterpenoid family displayed efficacy in FGF5 inhibition in vitro. A topical formulation containing a leading isolate significantly improved AT ratio, reduced hair fall and increased apparent hair density in the tested population of men and women.

Sanguisorba Officinalis root extract (SO extract) as an effective FGF5 inhibitor and demonstrated that SO extract enhanced the multiplication of outer root sheath cells in vitro. Further, in vivo analyses indicated that while SO extract did not enhance the onset of growth, it significantly reduced the number of telogen-phase follicles and increased hair length. We subsequently tested a topical solution containing SO extract in a cohort of human participants vs. a placebo group in a double-blind study over a 4-month period. We observed significantly reduced number of shed hairs (~70% less shed hairs) and decreased number of soft hairs (vellus), while hair growth rate and anagen:telogen (AT) ratio were increased. Subjective assessments of effectiveness indicated that the extract was rated as somewhat effective, effective or very effective for 74% of the treated group vs. 25% of the control.

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  CF on Mon Mar 13, 2017 1:44 pm

Thank you, CS.

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  CausticSymmetry on Mon Mar 13, 2017 4:43 pm

Hairbeback wrote:What does this mean in English?

Yes, it's for topical use.

In adults who are not experiencing hair loss, 80–90% of hair follicles should be in a growth phase while those experiencing hair loss tend to present with low growth and/or anagen to telogen ratio. Fibroblast growth factor-5 is important in the transition of hair follicles out of growth or anagen phase in humans, therefore, blocking its activity should result in the lengthening of the growth phase for individual follicles. This simply increases the number of hairs in the active growth phase instead of in a catatonic/dormant or resting phase.

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  cdto2012 on Sat Mar 18, 2017 5:04 am

Guess you want to be careful to get the root extract instead of the leaf.

"Polysaccharides extracted from Sanguisorba officinalis displayed antioxidant activities[3] .Ethanol extracts of Sanguisorba officinalis roots were shown to exert anti-inflammatory effects.[4] The root extract was also shown to have an anti FGF5 inhibitory effect which resulted in reduced hair loss.[5] "

https://en.wikipedia.org/wiki/Sanguisorba_officinalis

looks like it has been used in China for a long time

" It has been used in Traditional Chinese Medicine (TCM) where it is known by the name Di Yu. It is said to cool the blood, stop bleeding, clear heat, and heal wounds. (Chinese Herbal Materia Medica by Dan Bensky)

Specifically, the root is used to stop bloody dysentery, nosebleeds, and is applied topically to treat burns and insect bites "

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  splohocky on Sun May 07, 2017 7:21 pm

CS - have you tried using this? Do you have a brand you'd recommend? These results sound pretty incredible.

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  CausticSymmetry on Tue May 09, 2017 3:08 am

splohocky wrote:CS - have you tried using this? Do you have a brand you'd recommend? These results sound pretty incredible.

I am awaiting feedback on someone who has been using it. I'll report back if I hear of any results. I've never tried it.


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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  splohocky on Tue May 09, 2017 12:56 pm

CausticSymmetry wrote:
splohocky wrote:CS - have you tried using this? Do you have a brand you'd recommend? These results sound pretty incredible.

I am awaiting feedback on someone who has been using it. I'll report back if I hear of any results. I've never tried it.


I purchased some from the link you provided. I'll send updates once I start using it!

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

Post  splohocky on Sat May 13, 2017 6:25 am

So I read the entire study (quite fascinating), and apparently it's in relation to an Australian product called Evolis https://www.evolisproducts.com.au

The incredible results detailed in the study are in relation to a new formula containing isolates from several different actives, not just the root extract above. I've written them to see if their current product reflects the formula in this study, because if so, it sounds like a really incredible, natural product to add into any hair regimen.

I will update when/if I hear anything back from them!

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Re: Promotion of anagen, increased hair density and reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compounds via a novel 2-stage process.

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