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Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

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Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

Post  Joey Ramone on Fri Apr 07, 2017 11:13 am

Think you've been around long enough to see a few topicals come and go with varying degrees of success

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Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

Post  sizzlinghairs on Fri Apr 07, 2017 12:09 pm

True but I'm just trying to see what might currently be working. Trying to recondense current info

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Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

Post  CausticSymmetry on Sat Apr 08, 2017 3:23 am

Honestly, could fill up a page of 5-AR inhibitors, the list is a "mile" long, although 5-AR is just one part of the problem.

That said, here is an interesting one.

http://amzn.to/2oasPgE

Biomed Pharmacother. 2017 Feb 26;89:438-446. doi: 10.1016/j.biopha.2017.02.036. [Epub ahead of print]
Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss.

Wang ZD1, Feng Y1, Ma LY1, Li X1, Ding WF1, Chen XM2.

White wax (WW) has been traditionally used to treat hair loss in China. However there has been no reporter WW and its extract responsible for hair growth-promoting effect on androgenetic alopecia. In this paper, we examined the hair growth-promoting effects of WW and policosanol of white wax (WWP) on model animal of androgenetic alopecia and the potential target cell of WW and WWP. WW (1, 10 and 20%) and WWP (0.5, 1 and 2%) were applied topically to the backs of mice. Finasteride (2%) was applied topically as a positive control. MTS assays were performed to evaluate cell proliferation in culture human follicle dermal papilla cells (HFDPCs). The inhibition of WW and WWP for 5α- reductase were tested in Vitro. Results showed more lost hairs were clearly seen in mice treated with TP only and TP plus vehicle. Mice which received TP plus WW and WWP showed less hair loss. WW and WWP showed an outstanding hair growth-promoting activity as reflected by the follicular length, follicular density, A/T ratio, and hair bulb diameter. The optimal treatment effect was observed at 10% WW and 1% WWP, which were better than 2% finasteride treatment. MTS assay results suggested that WW and WWP remarkably increased the proliferation of HFDPCs. Inhibitor assay of 5α- reductase showed that WW and WWP inhibited significantly the conversion of testosterone to dihydrotesterone, and the IC50 values of WW and WWP were higher than that of finasteride. In Conclusion, WW and WWP could act against testosterone-induced alopecia in mice, and they promoted hair growth by inhibiting 5α-reductase activity and HFDPCs proliferation. DPCs is the target cell of WW and WWP.


KEYWORDS:
5α- reductase; Androgenetic alopecia; Dermal papilla cells; Hair follicles; Policosanol from white wax; White wax

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Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

Post  sizzlinghairs on Sat Apr 08, 2017 4:43 am

Thanks for the link Immortal. I think my parentheses werent clear though.

I meant all topicals that do not have 5ar or antiandrogenic properties

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Re: Are there any natural topicals (non antiandrogenic/5ar blocking) that anyone has used to at least help thicken their hair/turn vellous thicker/terminal?

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