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KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

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KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  Reseeding on Mon May 08, 2017 6:53 pm

Haven't seen any posts about this. Just read an article about it. Very interesting. Has anyone else heard about this?


http://www.sciencealert.com/finally-scientists-have-discovered-the-cells-behind-grey-hair-and-baldness
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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  CausticSymmetry on Tue May 09, 2017 3:13 am

Nice! - Here's the abstract on this info as well:

Genes Dev. 2017 May 2. doi: 10.1101/gad.298703.117. [Epub ahead of print]
Identification of hair shaft progenitors that create a niche for hair pigmentation.

Liao CP1, Booker RC1, Morrison SJ2,3,4,5,6, Le LQ1,4,5.

Hair differentiates from follicle stem cells through progenitor cells in the matrix. In contrast to stem cells in the bulge, the identities of the progenitors and the mechanisms by which they regulate hair shaft components are poorly understood. Hair is also pigmented by melanocytes in the follicle. However, the niche that regulates follicular melanocytes is not well characterized. Here, we report the identification of hair shaft progenitors in the matrix that are differentiated from follicular epithelial cells expressing transcription factor KROX20. Depletion of Krox20 lineage cells results in arrest of hair growth, confirming the critical role of KROX20+ cells as antecedents of structural cells found in hair. Expression of stem cell factor (SCF) by these cells is necessary for the maintenance of differentiated melanocytes and for hair pigmentation. Our findings reveal the identities of hair matrix progenitors that regulate hair growth and pigmentation, partly by creating an SCF-dependent niche for follicular melanocytes.

KEYWORDS:
KROX20; hair follicle stem cell; hair matrix; hair pigmentation; hair shaft progenitor cell; stem cell factor (SCF)

Also the full study (long):

http://genesdev.cshlp.org/content/early/2017/05/02/gad.298703.117.long

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  YARO on Tue May 09, 2017 1:43 pm

Saw this as well on MSNBC, really interesting. I don't think anyone has mentioned KROX20 yet, any other thoughts on this CS?

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  shaftless on Wed May 10, 2017 1:03 am

Problem is it'll be another 5 to 10 yrs before it will be available to the public.

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  CausticSymmetry on Wed May 10, 2017 4:06 am

YARO wrote:Saw this as well on MSNBC, really interesting. I don't think anyone has mentioned KROX20 yet, any other thoughts on this CS?

It appears that a problem with myelination, or rather demyelination (uncover its cause or origin would be key).

Demyelination is a common problem these days (with Glyphosate, mineral deficiencies) and neurotoxic substances.)

Demyelination itself is characterized as a condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in the brain and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems. However, this also includes the peripheral nerves in the extremities.

So for example, diabetics acquire problems with myelination. They lack certain minerals (copper is a major player here) and other things that protect against demyelination. The mineral copper levels appear to effect the transcription of Krox-20 depending on the level.

Krox-20/EGR2, a transcription factor that governs the expression of myelin proteins and facilitates myelination.

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  helpmyhair1 on Thu May 25, 2017 5:47 am

Is there anything we can do now based on this new study? Or do we have to wait years before a product is developed?

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  Schitz Popinov on Thu May 25, 2017 8:50 am

Sweet.

Another new discovery that needs a decade of research.

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

Post  CausticSymmetry on Thu May 25, 2017 2:16 pm

I don't think any new research is needed (unless there is patent interest in synthetic drugs).

Boosting myelin (which is what Krox-20 affects), these nutrients help produce it.

Vitamin D3 or sunlight
Vitamin C
Iodine
Zinc, Copper
Vitamin B5, B12
Vitamin K2
Biotin
Folate

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Re: KROX20 - scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice

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