Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Dermal Blimp1 acts downstream of epidermal TGFβ and Wnt/β-catenin to regulate hair follicle formation and growth.

View previous topic View next topic Go down

Dermal Blimp1 acts downstream of epidermal TGFβ and Wnt/β-catenin to regulate hair follicle formation and growth.

Post  CausticSymmetry on Mon Sep 11, 2017 9:33 am

J Invest Dermatol. 2017 Jun 28. pii: S0022-202X(17)31773-6. doi: 10.1016/j.jid.2017.06.015. [Epub ahead of print]
Dermal Blimp1 acts downstream of epidermal TGFβ and Wnt/β-catenin to regulate hair follicle formation and growth.

Telerman SB1, Rognoni E1, Sequeira I1, Pisco AO1, Lichtenberger BM2, Culley O1, Viswanathan P1, Driskell RR1, Watt FM3.

Blimp1 is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. While in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblast is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla (DP) cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12.5 mouse dermal fibroblasts delayed HF morphogenesis and growth and prevented new HF formation following wounding. By combining targeted qPCR screens with bioinformatic analysis and experimental validation we demonstrated that Blimp1 is both a target and mediator of key DP inductive signalling pathways including TGFβ and Wnt/β-catenin. Epidermal overexpression of stabilised β-catenin was able to override the HF defects in Blimp1 mutant mice, underlining the close reciprocal relationship between the DP and adjacent HF epithelial cells. Overall, our study reveals the functional role of Blimp1 in promoting the DP inductive signalling cascade that initiates HF growth.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 11952
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Dermal Blimp1 acts downstream of epidermal TGFβ and Wnt/β-catenin to regulate hair follicle formation and growth.

Post  Biffy on Mon Sep 11, 2017 9:11 pm

What can be done to maintain or promote Blimp1?

Biffy

Posts : 288
Join date : 2013-03-26

View user profile

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum