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Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue

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Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue

Post  Hairbeback on Thu Dec 28, 2017 5:54 pm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740347/

Taro Koyama, PhD, MD,corresponding authora,b Kazuhiro Kobayashi, MD,a Takanori Hama,c Kasumi Murakami,c and Rei Ogawa, PhD, MDb
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Abstract
Objective: In this study, we evaluated the effect of scalp massage on hair in Japanese males and the effect of stretching forces on human dermal papilla cells in vitro. Methods: Nine healthy men received 4 minutes of standardized scalp massage per day for 24 weeks using a scalp massage device. Total hair number, hair thickness, and hair growth rate were evaluated. The mechanical effect of scalp massage on subcutaneous tissue was analyzed using a finite element method. To evaluate the effect of mechanical forces, human dermal papilla cells were cultured using a 72-hour stretching cycle. Gene expression change was analyzed using DNA microarray analyses. In addition, expression of hair cycle-related genes including IL6, NOGGIN, BMP4, and SMAD4 were evaluated using real-time reverse transcription-polymerase chain reaction. Results: Standardized scalp massage resulted in increased hair thickness 24 weeks after initiation of massage (0.085 ± 0.003 mm vs 0.092 ± 0.001 mm). Finite element method showed that scalp massage caused z-direction displacement and von Mises stress on subcutaneous tissue. In vitro, DNA microarray showed gene expression change significantly compared with nonstretching human dermal papilla cells. A total of 2655 genes were upregulated and 2823 genes were downregulated. Real-time reverse transcription-polymerase chain reaction demonstrated increased expression of hair cycle–related genes such as NOGGIN, BMP4, SMAD4, and IL6ST and decrease in hair loss–related genes such as IL6. Conclusions: Stretching forces result in changes in gene expression in human dermal papilla cells. Standardized scalp massage is a way to transmit mechanical stress to human dermal papilla cells in subcutaneous tissue. Hair thickness was shown to increase with standardized scalp massage.

Keywords: hair, dermal papilla cells, scalp massage, mechanobiology, stretching force

Hairbeback

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Re: Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue

Post  Xenon on Thu Dec 28, 2017 6:54 pm

LOL you don't give up trying to prove a point, do you? Sorry to burst your bubble, but this Rei Ogawa "experiment" has been posted numerous times, and LOLd at by many board members (not just myself). The nine men were not suffering from MPB to begin with. All they did, however, was promote some Panasonic head massaging device, and said it increased hair thickness after 24 weeks. Yeh... why not repeat the experiment on nine men who were bald, and let's see what the results are then... except they didn't bother doing that because they knew what the results would be: failure. Who would then bother buying some otherwise utterly useless device? If you want to waste your money, then go for it.
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Xenon

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Re: Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue

Post  Hairbeback on Thu Dec 28, 2017 6:59 pm

Considering reversing baldness would take months years....posting this study proves my point lets see if you're smart enough to see what it is

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Re: Standardized Scalp Massage Results in Increased Hair Thickness by Inducing Stretching Forces to Dermal Papilla Cells in the Subcutaneous Tissue

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