Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Detumescence Reloaded

View previous topic View next topic Go down

Detumescence Reloaded

Post  Hotspur on Sun Jan 14, 2018 7:06 am

Rob @ PerfectHairHealth.com has returned with a new paper published in a peer reviewed journal.

Years ago when Rob & JD Moyer promoted the benefits of scalp massage this forum was alight. You and I tried our own rendition of scalp massage and almost universally failed to recreate JD's results.

As I failed I began to scrutinize Choy's study in detail. I even phoned him. The weaknesses in his article included no peer review, a pay to publish journal and a study that was never replicated.

That aside, I've always liked the way Rob has conducted himself. Our email exchanges have been enthusiastic and helpful. I've felt he's a person who genuinely believes in the benefits of scalp massage ...

... Even if Choy is notably not featured in the citations of his paper:

https://perfecthairhealth.com/update-2018-published-research-paper/

Rob, to me at least, has distinguished himself from other bro-scientists inc. Danny Roddy. This article has challenged me to look afresh at scalp massage. Now we need Rob to publish more success stories.

Hotspur

Posts : 99
Join date : 2015-09-19

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Sun Jan 14, 2018 7:23 am

https://www.youtube.com/watch?v=VBk-3W0e0v4

Its common sense scalp massages are beneficial, you don't need a scientific study with that. Poor western Science is more behind then it believes

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Sun Jan 14, 2018 7:23 am


Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Sun Jan 14, 2018 7:30 am

You can wait your whole life waiting for a science paper that will most likely be inconclusive. Start doing stuff, lower inflammation, experiment, go to a doctor maybe 2 doctors get a blood, allergy test etc see what vitamins you need and get to work

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hotspur on Sun Jan 14, 2018 8:10 am

Hairbeback wrote:You can wait your whole life waiting for a science paper that will most likely be inconclusive. Start doing stuff, lower inflammation, experiment, go to a doctor maybe 2 doctors get a blood, allergy test etc see what vitamins you need and get to work

Lol. I take it you're a NW1? Peer reviewed papers are helpful.

Hotspur

Posts : 99
Join date : 2015-09-19

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Sun Jan 14, 2018 3:39 pm

Helpful.....maybe....most peer review are poorly constructed and biased. You have to use intuition also

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hotspur on Sun Jan 14, 2018 6:56 pm

Hairbeback wrote:Helpful.....maybe....most peer review are poorly constructed and biased. You have to use intuition also

Nobody here is stating peer reviewed papers are infallible (As stated in your new thread). You're living in a fantasy world.

We're simply stating peer reviewed research is more credible than a random blog post.

Hotspur

Posts : 99
Join date : 2015-09-19

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Mon Jan 15, 2018 6:22 am

It is in theory, never claimed a blog post was

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hotspur on Mon Jan 15, 2018 9:42 am

And what did you think of Rob's paper?

Hotspur

Posts : 99
Join date : 2015-09-19

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Mon Jan 15, 2018 11:08 am

Going to check it out tonight can't wait

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Mon Jan 15, 2018 5:24 pm

I skimmed through the study as its late and my mind is foggy. Maybe this is out of context, but this is the conclusion I reached and many others have reached.

More vitamin K2 is also needed, no wonder the bottom of my teeth are translucent, all the calcium is probably going to my arteries and cappillaries, which is why I have stiff cappillaries on the side of my nose

Its adding up

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Xenon on Tue Jan 16, 2018 2:13 pm

Hotspur, this isn't 'DT Reloaded', as you state, instead Rob has done a 180 turn around and is now saying that mechanical force / mechanotransduction is a major cause of inflammation and onset of AGA (what I have been warning everyone about for years). Scalp massage - as with CDtos bottle rolling technique (DT) induces mechanotransduction, and, according to the theory, is said to promote growth factors which lead to hair growth. These were also the continuous claims of Keanoseg.

So, take this into account for a moment. Rob previously claimed that he cured his ten year battle with baldness via conventional DT techniques (mechanotransduction), and did so within seven months. Now he is saying that mechanical force causes inflammation and baldness.

Here's what he submitted:

"Explaining TGF-β1 activation in AGA through mechanotransduction
If TGF-β1 is androgen-induced, why might TGF-β1 express more highly in AGA tissues versus secondary body and facial hair tissues? Evidence strongly implicates that this is due to mechanical tension.

One study found that mechanical tension from the GA matches the pattern and progression of AGA, with peak tension points corresponding to the first places of hair loss. AGA-prone hair follicles reside within the dermis and subcutaneous fat layers of the scalp, and these layers are fused with the GA as a singular unit. As such, tension from the GA carries into these fused tissues, and thereby AGA-prone hair follicles. The investigators concluded that TGF-β1 expression may result from the tension-mediated induction of the AR coactivator Hic-5/ARA55, and that a “stretch-induced and androgen-mediated mechanotransduction in DP cells could be the primary mechanism in AGA pathogenesis” [57].

Interestingly, TGF-β1 is not only activated by androgenic activity [54], but also by reactive oxygen species (ROS) [58]. ROS are found in AGA-prone tissues, and androgen-induced TGF-β1 in hair follicle DP cells is mediated by ROS [59]. Increased ROS activity may partly explain differences in TGF-β1 expression in body, facial, and AGA-prone follicle tissues.

Mechanical tension can also mediate ROS activity in muscle cells – specifically, muscle stretch [60]. Studies of mechanotransduction (i.e., the mechanisms by which mechanical forces are converted to biological stimuli) demonstrate that mechanical tension in skin, muscle, and bone tissues can alter pro-inflammatory pathways, cytokines, and signaling protein expression [61]. Mechanical tension has also been shown in periodontal tissues to induce cyclooxygenase-2 (COX-2) expression [62], a pathway activated during prostaglandin D2 (PGD2) synthesis. Cell-generated mechanical tension also upregulates TGF-β from stiff extracellular matrix [63].

Collectively, these findings highlight the presence of GA-transmitted mechanical tension in AGA onset alongside the induction of ROS, PGD2, and TGF-β1 – all of which are pro-inflammatory substances and overexpressed in balding scalps. This implies that the inflammation observed in AGA is likely tension-mediated, and that GA-transmitted tension may be the starting point of a chronic inflammatory cascade that results in baldness.

Chronic inflammation may, in turn, increase androgen activity. Studies show that DHT modulates the inflammatory response during acute wound healing [64]. In prostate tissues, DHT is shown to exert broad anti-inflammatory effects [65]. One study demonstrated that the pro-inflammatory cytokine interleukin 1 (IL-1) increases androgen metabolism in chronically inflamed gingivitis tissues and the periodontal ligament [66]. This verifies that androgen activity can be a response to inflammation, and that tension-mediated inflammation may increase DHT, AR, and TGF-β1 in AGA by inducing ROS and other pro-inflammatory biomarkers."

P.S. The author of the paper (Rob) is called Robert S. English. Anyone have any background info on him? All Google reveals is a dermatologist by the same name, but this guy can't be Rob as he is an MD with over 19 years experience in the field of medicine.
avatar
Xenon

Posts : 1552
Join date : 2012-05-03
Location : Alpha Draconis

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hotspur on Wed Jan 17, 2018 6:47 am

Lol. Rob was asked about your post in the comments section. Here's his reply:

Hey Maya — I cut out the quoted text since it was so large of a copied/pasted segment. But to answer your question — no, that’s not true. That user appears to be misunderstanding (and thereby mischaracterizing) the paper’s presentation of evidence alongside its actual hypothesis.

If I had to guess why, it seems like they’re under the impression that mechanotransduction is synonymous with mechanical force, and that mechanical force is synonymous with mechanical tension and chronic tension. This is an easy mistake to make — but if made, it leads to a false interpretation of the paper. Those terms are related, but they aren’t interchangeable.

The paper actually argues that if we can relieve chronic scalp tension while simultaneously promoting a wounding-healing environment in AGA tissues, we may be able to reverse AGA-related fibrosis and thereby achieve better hair recoveries. That’s why the nuance in terminology is so important.

Best,
Rob

Hotspur

Posts : 99
Join date : 2015-09-19

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Wed Jan 17, 2018 2:16 pm

Oh the irony, this is why I posted the the article about people misrepresenting science articles and not knowing what they mean. I was called "triggered" by Xenon. Oh the irony

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Xenon on Wed Jan 17, 2018 3:00 pm

Hotspur, what he is saying is, the overgrowth of skulls bones + surrounding musculature basically causes the scalp to be pulled downward and become tight against the skull, thereby causing cellular compression (mechanical tension). However, the end result is no different from pressing down with the fingers (mechanical force) - both would lead to cellular compression against the skull, and ultimately mechanotransduction. We could pretty much say the same thing about pillow compression or wearing a tight hat.

Also, DT is based upon using the finger presses to remove (non existent) layers of grease because this is what Choy argued was causing the skin to swell and the skin to stretch and become tight. This simultaneously creates mechanical force, and apparently growth factors to increase.

So, after promoting DT, and telling everyone that it cured his baldness, Rob is now pretty much suggesting that the scalp needs to be loosened, and we need to prevent mechanical force, as this is the culprit in AGA. This isn't DT, rather this is based upon Maliniak's method of loosening the scalp.

Oh, and he used Keanoseg's "progress" pics as proof of DT working? Really? Horseshoe hairline, then within 2 months, he has complete regrowth? I don't buy it for a second. You tried this method (as did countless others), and by your own admission, it made things even worse. Many more people came forward and said exactly the same thing -- even people who tried this for years. However, there will always be a get out of jail card excuse why it has all failed - 'You're not doing it right' 'You gotta do it 3 years', etc. i can't say I blame people for being confused about all of this. One is saying press down and induce mechanical force, now another is saying mechanical force must be reduced via scalp loosening.

Rob will keep saying whatever he wants to say so long as the $$ keep rolling in. If people literally buy into his bullshit, then more fool them. I have to hand it to him, he is a smart marketer, and is very savvy to the fact that baldness is big business. He's just not smart enough to bullshit me.
avatar
Xenon

Posts : 1552
Join date : 2012-05-03
Location : Alpha Draconis

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Wed Jan 17, 2018 3:58 pm

Damn Xenon is bitter

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Xenon on Thu Jan 18, 2018 12:10 am

I'd also like to add: Rob suggests the use of a boar brush, right? Again, like Maliniak's scalp loosening exercises, this was another failure (and boar brushing caused worse inflammation and hair loss), as reported by countless people. I knew this from my own experience because excessive combing / brushing (for stylistic reasons) was a major player in accelerating my own loss, so I knew exactly what others were in for.

All Rob has done is lurked on the boards and silently milked the minds of many on here, and elsewhere. Everything in his paper / ebook has come directly from past posts from CS, myself and others. He even PMd me a few years back to ask if he could use some of my info in the ebook he was compiling at the time, but he failed to realize that not only was my information at odds with boar brushing and DT, but the latter actually causes worse hair loss - something he never anticipated at the time.

Yes, he seems like a decent guy in his communications, but sincere? Nope. Any good marketer knows he has to win the trust of customers before they hand over their money. Would people seriously be willing to hand over their $$ if he had an attitude and was an abrasive asshole (like myself)? Of course not. It's pretty much comparable to a guy being overly nice to a girl he's just met because he must present a front that will win her heart, or he doesn't get the "goods" at the end of the night.

Rob is an alumni in economics / marketing (from the University of California); he knows how to make money pretty much out of nothing. But what can I say? If people are willing to hand their money over to him, and get a raw deal as a result, then that's their fault.

Oh well, Rob might just get a Lamborghini and a mansion out of all this yet.
avatar
Xenon

Posts : 1552
Join date : 2012-05-03
Location : Alpha Draconis

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Hairbeback on Thu Jan 18, 2018 4:50 am

How does one maintain a life with out making money? I don't know rob and just skimmed through his website and he is selling book packages and has free e-mails to get you started.
I have no problem with people charging anything, the packages are not that expensive and honestly if you research hair loss on your own you can probably get a long fine with out the packages and just the e-mail. A lot of scientists/researchers "borrow" information and theories and add their own spin to it. Science is a "constant" it doesn't just stop because someone can't interpret a study.

Which probably has been retracted

Hairbeback

Posts : 824
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Detumescence Reloaded

Post  Sponsored content


Sponsored content


Back to top Go down

View previous topic View next topic Back to top


 
Permissions in this forum:
You cannot reply to topics in this forum