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N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

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N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

Post  Biffy on Sat May 12, 2018 8:57 pm

J Investig Dermatol Symp Proc. 2017 Oct;18(2):S81-S84. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes.
Abstract

Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.

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Re: N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

Post  CausticSymmetry on Sun May 13, 2018 2:23 am

Biffy wrote:J Investig Dermatol Symp Proc. 2017 Oct;18(2):S81-S84. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes.
Abstract

Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.

Nice one, thank you Biffy


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Re: N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

Post  CF on Sun May 13, 2018 3:36 am

Great find, Biffy. Thank you.

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Re: N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

Post  sizzlinghairs on Sun May 13, 2018 6:04 am

Does this mean NAC would decrease testosterone?

I have been taking NAC for a while and while I like the fact pgd2 is blocked,

I really donít want to be decreasing my testosterone levels. I donít want to be taking anything at all that messes with my
Hormone balance whatsoever.

Please clarify CS. Thanks!

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Re: N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

Post  shaftless on Wed May 16, 2018 12:16 pm

To me it sounds like NAC isn't blocking pgd2...it just inhibits pdg2 from making extra testosterone which could add to the balding effect. Am I getting it right?

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Re: N-Acetyl-Cysteine (NAC) Effectively Inhibits Prostaglandin D2

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