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Those science minded, please help me figure out this dilemma

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Those science minded, please help me figure out this dilemma

Post  sizzlinghairs on Thu Aug 16, 2018 5:48 am

Hey guys.

I知 currently in a hair loss regimen dilemma.

I do manual therapy involving using a bamboo bristle brush by pressing down on the scalp and vigorously moving it around 10 min 3 x day. It is thought manual therapy works in part due to micro inflammation triggering growth signals. What also happens with this therapy is Formation of dead skin and then exfoliation of it.

My dilemma involves my use of a cafffeine topical in conjunction with this therapy. I recently stumbled on this study regarding the negative effects of topical caffeine on wound healing. Here is the abstract:


Abstract
The purine alkaloid caffeine is a major component of many beverages such as coffee and tea. Caffeine and its metabolites theobromine and xanthine have been shown to have antioxidant properties. Caffeine can also act as adenosine-receptor antagonist. Although it has been shown that adenosine and antioxidants promote wound healing, the effect of caffeine on wound healing is currently unknown. To investigate the effects of caffeine on processes involved in epithelialisation, we used primary human keratinocytes, HaCaT cell line and ex vivo model of human skin. First, we tested the effects of caffeine on cell proliferation, differentiation, adhesion and migration, processes essential for normal wound epithelialisation and closure. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) proliferation assay to test the effects of seven different caffeine doses ranging from 0キ1 to 5 mM. We found that caffeine restricted cell proliferation of keratinocytes in a dose-dependent manner. Furthermore, scratch wound assays performed on keratinocyte monolayers indicated dose-dependent delays in cell migration. Interestingly, adhesion and differentiation remained unaffected in monolayer cultures treated with various doses of caffeine. Using a human ex vivo wound healing model, we tested topical application of caffeine and found that it impedes epithelialisation, confirming in vitro data. We conclude that caffeine, which is known to have antioxidant properties, impedes keratinocyte proliferation and migration, suggesting that it may have an inhibitory effect on wound healing and epithelialisation. Therefore, our findings are more in support of a role for caffeine as adenosine-receptor antagonist that would negate the effect of adenosine in promoting wound healing.
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So my dilemma is- is the micro inflammation and exfoliation/emergence of new skin, being impaired by topical caffeine? Essentially, does this study regarding isolated cell applications and actually wounding be of concern regarding my application of topical caffeine?

Any feedback massively appreciated!

Edit: recently stumbled on another study that shows caffeine upregulates Keratinocyte production in hair follicle -https://www.ncbi.nlm.nih.gov/m/pubmed/24836650/

So don稚 know what to think :/

sizzlinghairs

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