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Three Streams for the Mechanism of Hair Graying.

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Three Streams for the Mechanism of Hair Graying.

Post  CausticSymmetry on Fri Aug 17, 2018 10:27 am

Ann Dermatol. 2018 Aug;30(4):397-401. doi: 10.5021/ad.2018.30.4.397. Epub 2018 Jun 28.
Three Streams for the Mechanism of Hair Graying.
Jo SK1, Lee JY1, Lee Y2, Kim CD2, Lee JH2, Lee YH1.


Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and seek to offer some new insights. The traditional view is that hair graying is caused by exhaustion of the pigmentary potential of the melanocytes of hair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are the key cells in play. Graying may be caused by defective MSC self-maintenance, not by any deficiency in bulbar melanocytes. Our previous study suggested that graying may be principally attributable to active hair growth. Active hair growth may produce oxidative or genotoxic stress in hair bulge. These internal stress may cause eventually depletion of MSC in the hair follicles. Taken together, hair graying may be caused by MSC depletion by genotoxic stress in the hair bulge. Hair graying may also be sometimes caused by dysfunction of the melanocytes by oxidative stress in the hair bulb. In addition, hair graying may be attributable to MSC depletion by active hair growth.

KEYWORDS:
Hair bulb; Hair bulge; Hair graying; Hair growth; Melanocyte stem cell; Melanocytes

Full: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029974/

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