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Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes.

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Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes.

Post  CausticSymmetry on Tue Sep 18, 2018 3:19 pm

Genet Test Mol Biomarkers. 2016 Apr;20(4):197-202. doi: 10.1089/gtmb.2015.0246. Epub 2016 Feb 11.
Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes.
Tasdemir S1, Eroz R2, Dogan H3, Erdem HB1, Sahin I1, Kara M4, Engin RI5, Turkez H6.
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AIMS:
Nucleolar organizer regions, also known as argyrophilic nucleolar organizer regions, are associated with ribosomal genes. The main function of the nucleolus is the rapid production of ribosomal subunits, a process that must be highly regulated to provide the appropriate levels for cellular proliferation and cell growth. There are no studies in the literature addressing the expression and function of nucleolar component proteins, including nucleophosmin, nucleolin and the upstream binding transcription factor (UBTF), in human follicular hair cells.

METHODS:
Nineteen healthy males who had normal and sufficient hair follicles on the back of the head, but exhibited hair loss on the frontal/vertex portions of the head and 14 healthy males without hair loss were included in the current study. Gene expression levels were measured by relative quantitative real time polymerase chain reaction.

RESULTS:
In the individuals suffering from alopecia, the total expression levels of nucleolin, nucleophosmin, and UBTF were lower in normal sites than in hair loss sites. Strong expression level correlations were detected between: nucleophosmin and nucleolin; nucleophosmin and UBTF, and nucleolin and UBTF for both groups.

CONCLUSIONS:
There was an association between human hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes.

PMID: 26866305 DOI: 10.1089/gtmb.2015.0246

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