Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Go down

Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  CausticSymmetry on Fri Sep 28, 2018 2:54 pm

Int J Mol Sci. 2018 Sep 14;19(9). pii: E2770. doi: 10.3390/ijms19092770.
Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.
Kang JI1, Yoon HS2, Kim SM3, Park JE4, Hyun YJ5, Ko A6, Ahn YS7, Koh YS8,9, Hyun JW10,11, Yoo ES12,13, Kang HK14,15.

Hair growth is regulated by the interaction between dermal papilla cells (DPC) and other cells inside the hair follicle. Here, we show the effect and action mechanism of mackerel-derived fermented fish oil (FFO) extract and its component docosahexaenoic acid (DHA) in the control of hair growth. The hair growth effect of FFO extract was evaluated by the culture method of vibrissa follicles and in vivo dotmatrix planimetry method. FFO extract increased the length of hair-fibers and enabled stimulated initiation into the anagen phase of the hair cycle. As expected, FFO extract significantly increased DPC proliferation. FFO extract induced the progression of the cell cycle and the activation of extracellular signal-regulated kinase (ERK), p38 and Akt. FFO extract induced nuclear translocation of β-catenin, a stimulator of anagen phase, through an increase of phospho-glycogen synthase kinase3β (GSK3β) level. Since various prostaglandins are known to promote hair growth in humans and mice, we examined the effect of DHA, a main omega-3 fatty acid of FFO, on DPC proliferation. DHA not only increased DPC proliferation but also upregulated levels of cell cycle-associated proteins such as cyclin D1 and cdc2 p34. These results show that FFO extract and DHA promote hair growth through the anagen-activating pathways in DPC.

KEYWORDS:
Akt; anagen; cell cycle progression; dermal papilla cells; docosahexaenoic acid; extracellular signal–regulated kinase; hair growth; mackerel-derived fermented fish oil; p38; β-catenin

Full Study: https://www.mdpi.com/1422-0067/19/9/2770/htm

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 12136
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  shaftless on Tue Oct 02, 2018 3:08 pm

So should it be used as a topical? Dissolve some DHA into alcohol and rub it on your head?

shaftless

Posts : 474
Join date : 2012-08-12

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  CausticSymmetry on Wed Oct 03, 2018 4:14 am

shaftless wrote:So should it be used as a topical? Dissolve some DHA into alcohol and rub it on your head?

Using it that way isn't advisable, but it will work taken internally.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 12136
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  MiamiSteve on Thu Oct 04, 2018 1:14 am

CausticSymmetry wrote:
shaftless wrote:So should it be used as a topical? Dissolve some DHA into alcohol and rub it on your head?

Using it that way isn't advisable, but it will work taken internally.

Thank you for the information CS
Could you possibly give us a couple of products that would be what is described in the finding?

MiamiSteve

Posts : 50
Join date : 2011-02-02

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  CausticSymmetry on Thu Oct 04, 2018 4:17 am

MiamiSteve wrote:
CausticSymmetry wrote:
shaftless wrote:So should it be used as a topical? Dissolve some DHA into alcohol and rub it on your head?

Using it that way isn't advisable, but it will work taken internally.

Thank you for the information CS
Could you possibly give us a couple of products that would be what is described in the finding?

The best bet is to use something like this: Probably would work better than Mackerel-Derived Fermented Fish Oil.
Apparently the fermentation seems to boost the effectiveness, who would've thought.

https://amzn.to/2OACU4l (tastes terrible, probably better to go with capsules)

https://amzn.to/2zOY5Yd (capsules)

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 12136
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  Rudiger on Thu Oct 04, 2018 9:38 am

Apparently DHA, especially in larger doses, increases PGE2 and nothing else. More evidence that it can help regrow hair. Has no one yet tried a fish oil topical?

Here's a study CS posted in another thread showing the increase in PGE2 from DHA. I believe this should work topically.

Prostaglandins Leukot Med. 1985 Mar;17(3):319-27.
Docosahexaenoic acid (C22:6 omega 3) and linoleic acid are anti-aggregatory, and alter arachidonic acid metabolism in human platelets.
Srivastava KC.

Effects of various concentrations (12.5-500 uM) of linoleic acid and docosahexaenoic acid (C22:6 omega 3)(sod. salt) were examined on the platelet metabolism of labelled arachidonate (AA) under two different incubation conditions. In the first platelets were pretreated with either fatty acid prior to incubation with labelled AA; and in the second incubation platelets were incubated with a mixture containing a fatty acid (linoleic acid or DHA) and labelled AA. At all concentrations the two fatty acids reduced the formation of TxB2. At lower concentrations (up to 200 uM) the fatty acids inhibited platelet cyclooxygenase as shown by a reduced formation of prostaglandins (PGs) and TxB2. At higher concentrations (400 and 500 uM), however, the fatty acids behaved differently. Although TxB2 formation was reduced, there was observed an increased formation of PGs. In DHA pretreated platelets only PGE2 increased (to double control values). Platelets pretreated with linoleic acid produced increased amounts of all PGs (PGF2 alpha, PGE2, PGD2), and this effect was greatest for PGE2 which increased by 5-6 fold of control values. DHA showed a dose-dependent inhibition of platelet aggregation induced by arachidonate, epinephrine and collagen.

Rudiger

Posts : 23
Join date : 2016-05-10

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  Mxssingno on Thu Oct 04, 2018 7:30 pm

Why is it not advisable to use DHA topically?

Don't know how relevant this is:
"Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120"
https://www.ncbi.nlm.nih.gov/pubmed/26747719

Mxssingno

Posts : 14
Join date : 2017-11-15

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  Joey on Sat Oct 13, 2018 6:19 am

The Blue Ice Royal Butter Oil / Fermented Cod Liver Oil Blend really had a positive effect on my skin. Skin much clearer after taking it. Not sure it had much effect on my hair though. However stopped using it after hearing of Dr. Kaayla Daniel 's report which alleged it was rancid. Decided to stop just to be on the safe side and not too sure what the current state of play is with it.

Joey

Posts : 76
Join date : 2009-11-07

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  1alexie on Tue Oct 16, 2018 4:53 pm

This surely is interesting, thanks for sharing it with us.

1alexie

Posts : 20
Join date : 2018-06-01
Age : 25

View user profile

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  CausticSymmetry on Wed Oct 17, 2018 4:41 pm

Joey wrote:The Blue Ice Royal Butter Oil / Fermented Cod Liver Oil Blend really had a positive effect on my skin. Skin much clearer after taking it.  Not sure it had much effect on my hair though. However stopped using it after hearing of Dr. Kaayla Daniel 's report which alleged it was rancid. Decided to stop just to be on the safe side and not too sure what the current state of play is with it.

Rancidity sounds bad....however it gets different when it's fermented. Fermentation brings it up a notch.

This is not an opinion but in fact it has been found in more than a few studies. Also, I should point out that even rancid
fish oil works to bring down inflammation. But when fermented to compared to non-fermented, fermented works better.

Certainly, this information will go against most experts, but then again almost every dietary sacred cow in the two decades has been wrong.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
avatar
CausticSymmetry
Admin

Posts : 12136
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways.

Post  Sponsored content


Sponsored content


Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum