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Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

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Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

Post  Mxssingno on Tue Oct 23, 2018 1:41 am

https://www.ncbi.nlm.nih.gov/pubmed/27459121

Platycladus orientalis (L.) Franco is traditionally known to potentiate hair growth promotion. However, there has been no report on its main active ingredient responsible for the hair growth activity. In the current work, cedrol as a major constituent from P. orientalis was evaluated for its potential on hair growth in vivo. Different concentrations of cedrol (10, 20 and 30mg/mL) were applied topically over the shaved skin of C57BL/6 mice and monitored for 21days. Results indicated that cedrol significantly promoted hair growth in a dose-dependent manner, particularly for the female mice. Both male and female mice groups treated with 30mg/mL cedrol required shorter time than the blank control and 2% minoxidil groups at different growth stages. Compared with the blank control (8.87mm) and 2% minoxidil (9.94mm) groups at 21days, the hair length of female mice treated with 30mg/mL cedrol showed a remarkable increase with the value of 11.07mm. Hair in male and female mice groups treated with 30mg/mL cedrol was heavier than the 2% minoxidil (38.2 and 35.9mg, respectively) groups with the weight of 42.6 and 45.2mg, respectively. Further observation of the hair follicle demonstrated that cedrol exerted a remarkable effect on the hair follicle length. These findings suggested that cedrol may be the main active ingredient of P. orientalis and have the potential of becoming a new hair growth promoter.

The paper says there are further studies underway into the mechanisms. There is a patent filed covering cedrol or cedrol derivatives for hair growth.

Platycladus orientalis is also known as Thuja orientalis or Biota orientalis. In Chinese medicine the leaves are considered a remedy for hair loss, some recipes call for applying alcohol tincture three times per day. There are some studies showing hair growth in animals, though the alcohol extract wasn't as strong as other extraction methods.

Cedrol crystals seem reasonably affordable. Will be interesting to see the outcome of the further studies.

Mxssingno

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Re: Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

Post  Rudiger on Tue Oct 23, 2018 2:07 am

Not trying to rain on your parade, but how applicable are these mouse studies, where they shave mice, apply something, and if it grows faster than the control it can have carryover into AGA? Wouldn't alopecia areata studies on humans be even more applicable, if still not perfect?

Anything grows hair on mice.

Rudiger

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Re: Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

Post  shaftless on Tue Oct 23, 2018 2:31 am

Yeah, there are probably lots of things that can make already-growing hair grow faster. No one cares about that. Those mice weren't genetically bald.

shaftless

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Re: Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

Post  Mxssingno on Tue Oct 23, 2018 4:53 am

Indeed. I found this particular instance interesting due to its historical use and that the identified active ingredient is easily obtainable.

Mxssingno

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Re: Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

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