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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  CausticSymmetry on Tue Feb 05, 2019 4:42 am

J Nat Med. 2019 Jan 31. doi: 10.1007/s11418-019-01280-0. [Epub ahead of print]
Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.
Sagayama K1, Tanaka N1,2, Fukumoto T3, Kashiwada Y4.

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1-5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

KEYWORDS:
Chaga mushroom; Hair growth; Human follicle dermal papilla cell; Inonotus obliquus; Lanostane-type triterpene

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  bocor on Tue Feb 05, 2019 3:29 pm

Interesting! Do you have a link for this study?
Im wandering if topical or internal would be better
Also reviews on other forums of drinking chaga tea and hair regrowth...

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  bocor on Sat Feb 09, 2019 5:17 am

I just ordered chaga tincture so i will be applying after minox

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  shaftless on Sun Feb 17, 2019 9:21 am

Holy crap! That guy was right. Can't remember his name now, but he had a really long thread last year about his homemade cilantro topical and then it morphed into a chaga topical that he swore by.

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  johndoe1225 on Sun Feb 17, 2019 11:22 am

shaftless wrote:Holy crap! That guy was right. Can't remember his name now, but he had a really long thread last year about his homemade cilantro topical and then it morphed into a chaga topical that he swore by.

Sage 1, so basically just use the chaga mushroom now and not the whole cilantro topical thing?  Is this stuff safe topically, someone mentioned the sting is intense.  I don't mind that, but if I get other weird symptoms like low blood pressure, I have panic disorder and I'll probably have a small panic attack or something.

I really want to try this though, I guess I could just spot-test it for my own peace of mind and then slowly build up.  

So would something like this be ok?

https://www.vitaminshoppe.com/p/om-organic-chaga-100-g-powder/oom1002

It's in powder form so I suppose I just mix it with some water or something? I really like buying powders and making it myself if it's simple.

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  bocor on Sun Feb 17, 2019 1:00 pm

I ordered alchohol tincture and yes stings too bad
I would suggest making a strong chaga tea and applying that

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  johndoe1225 Yesterday at 10:17 am

bocor wrote:I ordered alchohol tincture and yes stings too bad
I would suggest making a strong chaga tea and applying that

Thanks

Does it have to be alcohol or can I just use water?  Is the powder ok like I linked?  I like buying in bulk like that rather than a few tea bags.  Do you have any idea what ratio of liquid-powder I'd need?  Or does CS know? That's my main problem, making sure I get the mixture right so I'm not just wasting it.

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  bocor Yesterday at 12:31 pm

Anyones guess what the best concentration might be
Just experiment with boiling powder with waterto make a strong tea and keep refrigerated between uses.It might stain the scalp so if thats an issue you can wrap head with satan wrap after you apply topical to allow it to penetrate for half hour or so
You could also make a super concentrated tea or just mix the powder with liposomal base like phlogel which should help absorption and it might be the less messiest way as well

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  johndoe1225 Yesterday at 3:09 pm

bocor wrote:Anyones guess what the best concentration might be
Just experiment with boiling powder with waterto make a strong tea and keep refrigerated between uses.It might stain the scalp so if thats an issue you can wrap head with satan wrap after you apply topical to allow it to penetrate for half hour or so
You could also make a super concentrated tea or just mix the powder with liposomal base like phlogel which should help absorption and it might be the less messiest way as well

Ok thanks! Can I just make it like a regular tea, boil water, add the powder then take it off the heat and let it sit?

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

Post  Mxssingno Today at 1:00 am

Regarding the full text of the study, if you copy the Pubmed address into Sci-Hub it is available. The domain moves sometimes but at the moment it's sci-hub.tw

Looks like they tested an ethanol extract in the study. Websites with info about mushroom extracts suggest alcohol for triterpinoid extraction.

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Re: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells.

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