Search
 
 

Display results as :
 


Rechercher Advanced Search

Check Out Our Sponsors
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Latest topics
» Ashwagandha
Yesterday at 7:38 am by Weser

» Ginkgo Biloba 6000 mg safe?
Yesterday at 1:16 am by MikeGore

» Lots Of Gas Causing ANNOYING Symptoms, Which Anti-Gas Product Is The Most Natural?
Thu Mar 21, 2019 9:08 am by johndoe1225

» Stroke, Parkinsons and billberry
Thu Mar 21, 2019 8:40 am by Jdp710

» What is your current regimen?
Fri Mar 15, 2019 3:21 pm by 1alexie

» Movie Review - "Root Cause"
Thu Mar 14, 2019 11:15 pm by Zaphod

» 6 mtscp wasabi study
Wed Mar 13, 2019 1:19 pm by 1alexie

» Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
Sun Mar 10, 2019 3:21 pm by CF

» Dealing with grey hair
Fri Mar 08, 2019 10:16 am by calvicie

Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search

Hope in the present and the future

Go down

Hope in the present and the future

Post  CausticSymmetry on Mon Feb 01, 2010 3:58 pm


_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
CausticSymmetry
CausticSymmetry
Admin

Posts : 12179
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Hope in the present and the future

Post  Guest on Tue Feb 02, 2010 3:17 am

Pretty awesome, we were discussing this in Molecular Biology.

Guest
Guest


Back to top Go down

Re: Hope in the present and the future

Post  Hairbeback on Tue Feb 02, 2010 9:42 am

Very interesting and informing this topic deserves to be on the top...lol. Anyway I was wondering why they are trying to find chemicals to lengthen the telomeres and was wondering what about maybe a natural herb or something of that nature. I breezed through the tasciences.com website and it said their supplement was a nutracutical what is that exactly?

Hairbeback

Posts : 884
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Hope in the present and the future

Post  CausticSymmetry on Tue Feb 02, 2010 10:16 am

Hairbeback - It's cycloastragenol which comes from astragaloside IV.

There are astragaloside IV products on the market which are much cheaper than TA-65, however
they are not acid processed to convert the astragaloside IV into cycloastragenol.

I found this:

A acid process in methanol where the astragaloside molecule is converted to cycloastragenol - a common ring closing
reaction.

The naturally occuring astragaloside IV molecule is less potent than the cycloastragenol. The patent app above shows the relative potency vis telomerase for all of these molecules, so should be able to expect equal results from the other astragalus extract molecules (dosed equivalently per the patent app relative potency to equal the 5 mg TA-65 dosage effect). Their clinical results should be repeatable for the rest of us using this equivalency as shown in the patent application.

Excerpt from patent: Cycloastragenol is administered at a level of at least 1 mg/day, preferably at least 5 mg/day; or the compound designated herein as astragaloside IV is administered at a level of at least 50 mg/day, preferably at least 100 mg/day."

Example 1. Conversion of astragaloside IV(1) to cycloastragenol(2) To astragaloside IV (1) (5.00 g, mmol) was added"HCl-MeOH 10" (TCI America) (500 mL) and the mixture was stirred at room temperature for 7 days. The reaction mixture was concentrated to about half volume under reduced pressure at 20 C (do not heat). The mixture was
partitioned into aqueous sodium bicarbonate and ethyl acetate.

The aqueous layer was extracted with ethyl acetate again. The organic layers were combined, washed with saturated sodium chloride, dried on anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (20:1-14 : 1 chloroform/methanol). In order to replace the residual solvent with ethanol, the
purified material was dissolved in ethanol and the solvent was removed under reduced pressure to afford 2 (2.1 g, 64%).

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
CausticSymmetry
CausticSymmetry
Admin

Posts : 12179
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Hope in the present and the future

Post  Hairbeback on Wed Feb 03, 2010 2:03 am

I wonder what role who epigenetics have on the gene for producing telomeres in your DNA be?

Hairbeback

Posts : 884
Join date : 2009-04-02

View user profile

Back to top Go down

Re: Hope in the present and the future

Post  CausticSymmetry on Wed Feb 03, 2010 3:17 am

Hairbeback - Offhand, I know that curcumin and carnosine can delay the shortening of telomeres, and apparently so can astragalus.

It may take a drug to lengthening them, but hopefully I'm wrong.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
CausticSymmetry
CausticSymmetry
Admin

Posts : 12179
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Hope in the present and the future

Post  TK on Thu Feb 04, 2010 4:06 am

Hi CS,

What would an optimal dose of straight astralagus root be, in your opinion?( this IV stuff isnt available in Canada)

thanks!

TK

Posts : 79
Join date : 2010-01-22

View user profile

Back to top Go down

Re: Hope in the present and the future

Post  CausticSymmetry on Thu Feb 04, 2010 4:37 am

TK - Not sure if the exact, optimal amount of astragalus IV has been determined, however most of the research on Astragalus has been using astragalosides, and apparently, the extract of astragalus, standardized to 0.3% astragalosides is purported to allow optimal therapeutic activity.

Some suggest taking 500 mg of the extract two to three times daily.

_________________
My regimen
http://www.immortalhair.org/mpb-regimen

Now available for consultation (hair and/or health)
http://www.immortalhair.org/health-consultation
CausticSymmetry
CausticSymmetry
Admin

Posts : 12179
Join date : 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Hope in the present and the future

Post  tonyj on Thu Feb 04, 2010 5:02 am

I forgot where I saw the original study, but it appears, for women anyway, that taking multivitamins with anti-oxidants is associated with longer telomeres. Don't know if the same is true for men.

http://www.ajcn.org/cgi/content/abstract/89/6/1857
tonyj
tonyj

Posts : 390
Join date : 2009-10-03

View user profile

Back to top Go down

Re: Hope in the present and the future

Post  Sponsored content


Sponsored content


Back to top Go down

Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum