The promise of slow down ageing may come from curcumin

Curr Pharm Des. 2010;16(7):884-92.

The promise of slow down ageing may come from curcumin.
Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K.

Laboratory of Molecular Bases of Ageing, Nencki Institute of Experimental Biology, PAS, Warsaw, Poland. e.sikora@nencki.gov.pl

Abstract
No genes exist that have been selected to promote aging. The evolutionary theory of aging tells us that there is a trade-off between body maintenance and investment in reproduction. It is commonly acceptable that the ageing process is driven by the lifelong accumulation of molecular damages mainly due to reactive oxygen species (ROS) produced by mitochondria as well as random errors in DNA replication. Although ageing itself is not a disease, numerous diseases are age-related, such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others, likely caused by low grade inflammation driven by oxygen stress and manifested by increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha, encoded by genes activated by the transcription factor NF-kappaB. It is believed that ageing is plastic and can be slowed down by caloric restriction as well as by some nutraceuticals. As the low grade inflammatory process is believed substantially to contribute to ageing, slowing ageing and postponing the onset of age-related diseases may be achieved by blocking the NF-kappaB-dependent inflammation. In this review we consider the possibility of the natural spice curcumin, a powerful antioxidant, anti-inflammatory agent and efficient inhibitor of NF-kappaB and the mTOR signaling pathway which overlaps that of NF-kappaB, to slow down ageing.

CS, what do you recommend to slow down the aging process? Resveratrol? TA65? I know antioxidants don't help.

Also what age would one need to start (sometime around the age of 25?)

goten574 - Where did you hear that antioxidants do not help?

Supplying electrons via antioxidants will allow for longer life. Longer life with antioxidants, especially
ALC/ALA, E-Cava and other ways to boost GSH (Glutathione) and other antioxidant enzymes.

what do you think of astragalus?

I've done a bunch of research and would have to agree with CS regarding electron depletion. As CS posted the video previously, root canals are a huge problem. So is chlorine and flouride for depleting your electron stores. The chlorine would come from long, hot showers if your water is chlorinated. Stomach acid, enzymes and saliva all contain large amounts of electrons. Keeping levels up as you get older would be a good idea.

I personally take Patrick Flagan's Mega H/Mega Hydrate and/or the Hydrogen Water Stick. I also take enzymes as well.

There are other ones to live to 120 but I believe in these the most. Two others that stand out the most would be ubiquinol and/or hyaluronic acid.

I agree with jdp710, and should add one more thing. The less excess on insulin levels the longer we live. This principle is the epitomy of the top 6 regimen.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831640/

CausticSymmetry wrote:goten574 - Where did you hear that antioxidants do not help?

Supplying electrons via antioxidants will allow for longer life. Longer life with antioxidants, especially
ALC/ALA, E-Cava and other ways to boost GSH (Glutathione) and other antioxidant enzymes.

I watched a 2010 BBC documentary about aging and lucky enough, it has been posted on Youtube here. The antioxidants part of the documentary is talking about oxidative stress so I don't think that's what you're talking about. Multiple tests over 10 years showed that it's possible to have high levels of oxidative stress and still have a long life so oxidative stress does not make a difference in aging. See part 2 (from 4 minutes) and part 3 of that video for more information.

This was why I said I don't think antioxidants can help with aging, because of that oxidative stress theory. The documentary is good, I recommend it but I do not know how accurate it is.

goten574,

This video helps to explain why those 2 other studies didn't pan out in the BBC video.

http://www.youtube.com/watch?v=6MofRjD2UaY

At 5:20 it talks about the naked mole rat as well.

One thing in the BBC documentary if you notice that heavy guy definitely does look much younger! I'm betting he has a large amount of estrogen ----> hyaluronic acid.

hope this helps

CS, you're absolutely right about insulin being key to longevity ... forgot about that. mercola just had a recent article about on why caloric restriction works ----> lower insulin. Mercola's information is nothing new though.

goten574 - As good as the BBC is for documentaries on nature subjects, it is like many other media sources, horrible in terms of accuracy with respect to health.

Anytime I hear anything on mainstream channels about health, it is reduced to mediocrity and far from current day science. Instead, we hear extremely conservative beliefs that existed decades ago. This is the norm.

This link here in the previous thread on humans, further supports a 2006 study on rats, showing that it is the lowering of insulin that allows longer life.

In order to keep insulin levels low, antioxidants, especially those that increase the activity of antioxidant enzymes will improve insulin sensitivity and lowering insulin even under some adverse hyperglycemic conditions.

More info here: http://www.freewebs.com/immortalhair/theoryinpractice.htm

In a nutshell, increasing the production of endogenous antioxidant enzymes will lower insulin levels and increase lifespan. This is stated

CausticSymmetry wrote:goten574 - As good as the BBC is for documentaries on nature subjects, it is like many other media sources, horrible in terms of accuracy with respect to health.

Anytime I hear anything on mainstream channels about health, it is reduced to mediocrity and far from current day science. Instead, we hear extremely conservative beliefs that existed decades ago. This is the norm.

Well I would like to add that the scientists in that documentary thought the reason why antioxidants may help aging was because of reduced oxidative stress but this wasn't so. In the documentary one scientist says he hasn't given up on antioxidants yet.

Thanks for the links guys, I will check them out shortly!

jdp710 wrote:goten574,

This video helps to explain why those 2 other studies didn't pan out in the BBC video.

http://www.youtube.com/watch?v=6MofRjD2UaY

Great video, jdp. Interesting – in another thread we were talking about Fo-ti. Longevinex (who created the video) has a product which is primarily Giant Knotweed. Apparently, knotweed is a great source (among other things) of resveratrol. Now, from what I understand, Giant Knotweed is the main ingredient of Fo-ti. Good times. . .

TA65 and any other telomerase activator actually cannot be taken with Resveratrol. They're antagonistic to each other, and will cancel out the telomerase-activating properties.