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How to shrink the follicles' sebaceous glands?

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How to shrink the follicles' sebaceous glands?

Post  hoppipolla on Sun May 09, 2010 2:45 am

I reckon this could be a killer. I mean at the moment, I am trying to reduce fungal activity, dandruff, remove dead skin cells, clear surface sebum, all that stuff, just to improve the conditions of my scalp. HOWEVER. Let's not forget the actual cause of all this junk..... sebum!

So like.. is lithium (topically or orally) enough to actually SHRINK sebaceous glands? Because it does seem that they get swollen with possibly IGF-1-triggered sebum, maybe fat, and certainly DHT.

Oh my apparently accutane does it.. *shudders*

Apparently "vitamin A acid isotretinoin (13-cis retinic acid)" (WHATEVER that is..) does it too.


But yeah erm, does anybody know about this? If lithium does it then I'll give that a bash, but I think this would be a great (topical or systemic) move in controlling hair loss for pretty much anyone, as so many people say their hair loss coincided with a bout of sebum or dandruff.


Hoppi!

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Re: How to shrink the follicles' sebaceous glands?

Post  CausticSymmetry on Sun May 09, 2010 3:51 am

Hoppipolla - Accutane is a real disaster (check out older posts).

As far as sebaceous hyperplasia is concerned, it is in part due to an imbalance of Omega-6 and Omega-3 fatty acids, which relate to prostaglandin problems.

Several omega-6 fat compounds exacerbate inflammation, and there are subsequent enzyme intermediates, which turn omega-6 fat into potent incendiary compounds in the skin. Primarily 5-LOX, which turns the omega-6 fat, arachidonic acid, into potent leukotrienes.

You'll find that naturally inhibiting 5-lipoxygenase (5-LOX) directly reduces sebum production.

Then there is an anti-inflammatory Omega-6 called GLA, this is also good.

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Re: How to shrink the follicles' sebaceous glands?

Post  Paradox on Sun May 09, 2010 4:40 am

Yes, retin-A is known to shrink pores and reduce sebum as far as I remember. CS, do you know of any reason that retin-a should be used with caution? Everything I've read about it seems positive as far as skin aging and collagen goes.

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Re: How to shrink the follicles' sebaceous glands?

Post  hoppipolla on Sun May 09, 2010 5:36 am

Ah ok thank you CS! Will the good quality fish oil I am taking (soon to be replaced with krill oil!) fix this problem then? I'm on about 1-2000mg per day Smile

And also that was the term I was looking for - "sebaceous hyperplasia"!

So like, when someone has MPB, I would imagine that fairly often they have this condition too? Will it gradually go back to normal once the sebum production has been reduced by things like lowering IGF-1 levels and improving the omega 3/omega 6 balance?

I ask because I am wondering if SH is in fact one of the reasons people often claim that MPB cannot be completely "reversed" and cured, because the sebum level is still too high, meaning an upset scalp and higher levels of DHT. Of course I too believe there are other reasons, but I could understand how this could be a significant almost.. turning point in the development of MPB.

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Re: How to shrink the follicles' sebaceous glands?

Post  hoppipolla on Sun May 09, 2010 11:45 pm

Ah about the 5-LOX thing, they were talking about this a while back on an acne message board I just found - http://www.acne.org/messageboard/sebum-supression-move-a-t140399.html

Unfortunately things seemed a little mixed. On the plus side though green tea, ginger and curcumin all inhibit 5-LOX, and look at the ingredients of a mild topical I will soon be using:

http://www.endhairlossnaturally.com/hair.loss.ingredients.DHT.htm


I know it's probably intended as some weird scam but.. I love that stuff! lol

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Re: How to shrink the follicles' sebaceous glands?

Post  boxter on Mon May 10, 2010 6:46 pm

Hi All

I would also be interested to know of any supplements that can shrink sebaceous glands or significantly reduce sebum production. Does anyone have any ideas what can be used and dosages etc.
Can LLLT help with this?

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Re: How to shrink the follicles' sebaceous glands?

Post  CausticSymmetry on Mon May 10, 2010 6:59 pm

boxter - This topical works pretty well for reducing sebum on the scalp.

http://www.immortalhair.org/topicals.htm

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Re: How to shrink the follicles' sebaceous glands?

Post  hoppipolla on Tue May 11, 2010 2:15 am

I think at some point I'll just start experimenting with adding lithium and DMSO to my main shampoo Smile

I think that coupled with low IGF-1, good diet, krill oil, curcumin inhibiting 5-LOX, all that should start cutting into that sebum production, and I'm guessing that over time the sebaceous glands will just shrink by themselves?

The only reason I was a little kinda.. nervous about the topical is because of possible reactions, etc. So, for those not particularly sensitive to the lithium, is it quite easy on the scalp? Because I have always gone for things that are very kind on my scalp (that's why I steered clear of SLS, etc), and so of course the idea of lithium and DMSO just makes me a little bit cautious! Smile

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Re: How to shrink the follicles' sebaceous glands?

Post  tao81 on Tue May 11, 2010 3:58 pm

topical retin a does the job very good

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Re: How to shrink the follicles' sebaceous glands?

Post  j87x on Tue May 11, 2010 4:56 pm

CausticSymmetry wrote:boxter - This topical works pretty well for reducing sebum on the scalp.

http://www.immortalhair.org/topicals.htm

A couple questions on the DMSO shampoo - what happens if you accidentally get some in your eyes, can you just wash it out? Also will the DMSO further the penetration of fluoride/chlorine from the water into your bloodstream?

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Re: How to shrink the follicles' sebaceous glands?

Post  hoppipolla on Tue May 11, 2010 7:14 pm

tao81 wrote:topical retin a does the job very good

oo really? Yes I've heard good things about Retin A but know relatively little about it - do you think it would work for this then? Smile

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Re: How to shrink the follicles' sebaceous glands?

Post  tao81 on Tue May 11, 2010 9:51 pm

yes retin a works i use it myself an it reduces sebum an shrink pores. I use it in my face as well and there i can see a significant decrease in sebum an pore size

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