Search
 
 

Display results as :
 


Rechercher Advanced Search

Latest topics
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Natural Hair Growth Products
Brought to you by
Hair Loss Forum
Navigation
 Portal
 Index
 Memberlist
 Profile
 FAQ
 Search
Natural Hair Growth Products
Brought to you by
Hair Loss Forum

Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Page 1 of 8 1, 2, 3, 4, 5, 6, 7, 8  Next

View previous topic View next topic Go down

Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sat Feb 05, 2011 3:35 am

BMB Rep. 2010 Oct;43(10):688-92.
Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells.
Kwack MH, Ahn JS, Kim MK, Kim JC, Sung YK.

Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700-422, Korea. ysung@knu.ac.kr

In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding.

Click here for full study http://www.bmbreports.org/jbmb/pdf.php?data=MTEwMjA1MDJAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0My0xMCU1RDExMDEyODA4NTNfJTI4Njg4LTY5MiUyOUJNQjM5MiUyODEwLTEzMiUyOS5wZGY=

Related studies:

http://www.ncbi.nlm.nih.gov/pubmed/17657240

http://www.ncbi.nlm.nih.gov/pubmed/20701628

http://www.ncbi.nlm.nih.gov/pubmed/12397096

http://www.ncbi.nlm.nih.gov/pubmed/19416266

http://www.ncbi.nlm.nih.gov/pubmed/16536801

In the last three months have tried Threonic Acid enhanced buffered ascorbate (Transport C-PLUS) and
a little later on Calcium L-Threonate, which is better supported than using L-Threonate or Threonic acid alone.

Magnesium L-Threonate has not been approved by the FDA yet, so will have to wait on that.

So far, no hair has fallen out, but it's hard to say if anything new has happened. It will take a good 6-months to
really know anything for certain.

So far the best price on Calcium L-Threonate is from www.Amazon.com

I have not yet tried this transdermally, so if anyone wants to try using this with a little DMSO and water, that could be an interesting experiment.

In an old patent, Calcium L-Threonate was claimed to be a very potent treatment of osteoporosis. DKK-1 is a major factor in osteoporosis, because when Wnt proteins are inhibited, just like hair loss, there is bone loss.

_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sat Feb 05, 2011 4:19 am

Raxe - DKK-1 or dickkopf-1 is a specific ligand for LRP6 (LDL-receptor-related protein 6) acting as a Wnt co-receptor.

DKK-1 blocks LRP6-mediated Wnt/beta-catenin signaling, which is required for hair growth

Regarding other functions, Wnt protein signaling in osteoblasts is necessary to promote BMP-2-mediated differentiation of pre-osteoblast cells, and therefore, DKK1 may play a key role in regulating pre-osteoblast differentiation and the development of multiple myeloma-associated osteolytic bone lesions.

Treatment of reconstructed skin with DKK1 reproduces the hypopigmentation and thickening of skin through Wnt/beta-catenin signaling. DKK1 may be useful for reducing skin pigmentation and for thickening photo-aged skin and palmoplantar wounds caused by diabetes mellitus and rheumatic skin diseases.

DKK-1 is needed by the body, Calcium L-Threonate is metabolite of vitamin C.



_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sat Feb 05, 2011 4:52 am

act<react - Yes, and so far nothing to report (positive or negative). I've tried a few different forms so far. I'm sticking to Calcium L-Threonate since the studies bear this out to be the most effective. I use a product called BioCalth.

Amazon has it at the lowest price.

_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  act<react on Sat Feb 05, 2011 5:06 am

CausticSymmetry wrote:act
Amazon has it at the lowest price.

I'm going to give this a shot, then do some experimentation, the thirty month window would be a little more kind to me I'd think so results might be more apparent, as I've already pretty much nailed my hair loss (or slowed it to a dead crawl).

Any specifics I should be aware of would be appreciated!

act<react

Posts: 800
Join date: 2011-01-21
Age: 24

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sat Feb 05, 2011 5:40 am

act<react - Yes, almost forgot. Based on an old patent for osteoporosis, it suggests 3 grams per day as dosage.

This is roughly what BioCalth recommends also. I'm taking three tablets per day, usually with meals (but it probably doesn't matter).




_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  act<react on Sat Feb 05, 2011 6:03 am

CausticSymmetry wrote:act
This is roughly what BioCalth recommends also. I'm taking three tablets per day, usually with meals (but it probably doesn't matter).




Woh! I was thinking this was topical, hahah, I'm going to hit it from both angles with the DMSO / Lithium (not necessary?) and a couple other goodies eventually if I see any synergy in rejuvenation.

act<react

Posts: 800
Join date: 2011-01-21
Age: 24

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  DM5 on Sat Feb 05, 2011 6:24 am

Looks great, CS! Will take the tabs first for a couple weeks and then may crush and add to Seveov topical. May also drop other things from my stack for awhile to get a good baseline measure.

_________________
Occupy Monsanto

May 25th 2013

March Worldwide

Like March Against Monsanto on Facebook

DM5

Posts: 530
Join date: 2009-06-08

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  nidhogge on Sat Feb 05, 2011 11:11 am

Hell, I'll give this stuff a spin as well for a while. If it works for us, maybe we'll have to consider adding the product to the Ortho Nutrition line for a more affordable price.

_________________
Interested in a Laser Helmet, or curious about how you can utilize LLLT (Low-Level Laser Therapy) treatments in our fight against Hair Loss in general? Then, by all means, feel free to drop me a private message!!!

nidhogge

Posts: 2145
Join date: 2008-07-10

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  bug on Sat Feb 05, 2011 1:58 pm

I'm glad you did the right thing by posting this...my work here is done Smile

bug

bug

Posts: 1
Join date: 2011-02-02

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  mphatesmpb on Sat Feb 05, 2011 3:05 pm

What distinguishes L-threonate from proanthocyanidins? There were some pretty convincing in vitro studies showing that proanthocyanidins, when added to a co-culture of dermal papilla cells and outer root sheath, prevented the DHT-induced apoptosis of the ORS cells. The only thing that seems to have become of proanthocyanidins is a sorry ass website full of cheap marketing ploys that spell out "scam."

mphatesmpb

Posts: 621
Join date: 2010-10-21

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sat Feb 05, 2011 6:12 pm

mphatesmpb - The interest is the mechanism, because DKK-1 is probably the most formidable factor in androgen driven baldness. Still, it will be a little while for this to prove itself, because it could easily wind up as another proanthocyanidin, or even do less. The encouraging thing though is calcium L-threonate is as effective as estrogen in inhibiting DKK-1, and it has already been proven to promote collagen regeneration.





_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  scottyc33 on Sat Feb 05, 2011 11:02 pm

CausticSymmetry wrote: The encouraging thing though is calcium L-threonate is as effective as estrogen in inhibiting DKK-1, and it has already been proven to promote collagen regeneration.


So good for hair and skin?

CS - any potential negative side effects you can think of from taking this stuff?

I am going to try this for 4-6 months beginning 3/1.


_________________
Immortal Hair Supplement Line - Ortho Nutrition
Antioxidant Boost (Resveratrol, Curcumin, Sulforaphane)
R-ALA
Ecklonia Cava
Krill Oil
Decalcify
Rejuvaplex Topical

Other
Ubiquinol
ALCAR
Liv 52
Iodine
Ashwagandha

SUPERFOODS: Energy First and Sun Warrior Protein, Dessicated Liver, Concentrace, Colostrum, Brewers Yeast, Fermented Cod Liver & High Vitamin Butter Oil

scottyc33

Posts: 1131
Join date: 2008-08-11

View user profile

Back to top Go down

Re: Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-induced dickkopf-1 expression in human hair dermal papilla cells

Post  CausticSymmetry on Sun Feb 06, 2011 3:16 am

scottyc33 - It has no toxicity or side effects.

http://www.nutraingredients.com/Regulation/Calcium-L-threonate-safe-for-use-in-supplements-says-EFSA

The worst that will happen is that it won't grow hair. Some of the side-benefits are improvement in conditions such as rheumatoid arthritis (because it improves collagen problems), and osteoporosis.




_________________
My regimen
http://www.immortalhair.org/mpbregimen.htm

Now available for consultation (hair and/or health)
http://www.immortalhair.org/hairconsultation.htm

CausticSymmetry
Admin

Posts: 10991
Join date: 2008-07-09

View user profile http://www.immortalhair.org/

Back to top Go down

Page 1 of 8 1, 2, 3, 4, 5, 6, 7, 8  Next

View previous topic View next topic Back to top

- Similar topics

Permissions in this forum:
You cannot reply to topics in this forum