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Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

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Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  a<r on Thu Jan 19, 2012 7:02 pm

In the past two years a lot has come to light on this site regarding disease and bacterias role in it, thus far we've learned that some of the essentials in improving conditions related to this are managing a dopey thryoid, improving the ratio of organic to oxidized minerals and metals, removal of heavy metals, natural anti-biotics and anti-parasitics, rest, positive thinking and stress / endocrine stress hormone management, the list goes on for miles and I'm forgetting many probably obvious ones.

Since last years initial three month herx nightmare following the intense chelation rounds, I've tapered out in health and have only made small gains since by modulating my diet, which leans towards elimination of starches, plenty of natural fruit sugars combined with plenty of raw meat, cocnut oil, whey, vinegars, and soluble fiber as found mostly in apples. Over the summer I tipped many scales by messing around with fasting and massive sunshine intakes, and the result was similar to the chelation.

I've been researching biofilm for quite a while and though I didn't have any evidence to directly say it was important, I stuck with it. Well, I recently started enteric coated serrapeptase, nattokinase, and I've started back again going through the craziness that is random and induced herxheimer reactions. I'm not long home from work but my experiences are very much similar to what I went through last year, wayyy too tired to repost all that right now.. Instead I'm going to propose that you read what I am about to post and dig further, and say that perhaps if you aren't chelating well or "detoxing" well, this may be for you.

On an aside, I'm craving sugar like a six year old, any suggestions as to why?

Enzymes normally found in the body are needed for each of the millions of biochemical reactions in our body. Without these enzymes, human life could not exist. Enzymes are proteins that act as catalysts, speeding the rate at which biochemical reactions proceed but not altering the direction or nature of the reactions. Enzymes are found in every cell of every living plant and animal, including humans. As biocatalysts, they either begin a reaction or cause a reaction to speed up. Systemic enzyme supplementation utilizes an abundance of enzymes to increase the total number of enzymes throughout the body to assist normal, healthy functions.



Fibrin (also called Factor Ia) is a tough protein substance that is arranged in long fibrous chains; it is involved in the clotting of blood, and is non globular. It is a fibrillar protein that is polymerized to form a "mesh" that forms a hemostatic plug or clot (in conjunction with platelets) over a wound site. Fibrin is made from fibrinogen, a soluble plasma glycoprotein that is synthesized by the liver and found in blood plasma.



Fibrin is involved in the following biological processes: signal transduction, blood coagulation, platelet activation, and protein polymerization.



Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process, due to injury or long-term inflammation.



Fibrin (also called Factor Ia) is a tough protein substance that is arranged in long fibrous chains; it is involved in the clotting of blood, and is non globular. It is a fibrillar protein that is polymerized to form a "mesh" that forms a hemostatic plug or clot (in conjunction with platelets) over a wound site. Fibrin is made from fibrinogen, a soluble plasma glycoprotein that is synthesized by the liver and found in blood plasma.



Fibrin is involved in the following biological processes: signal transduction, blood coagulation, platelet activation, and protein polymerization.



Fibrosis is the formation or development of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process, due to injury or long-term inflammation.



Serrapeptase

Serrapeptase, also known as serratiapeptase, serratia peptidase, serratio peptidase, or serrapeptidase, is a proteolytic enzyme isolated from the non-pathogenic enterobacteria Serratia E15. When consumed in unprotected tablets or capsules, the enzyme is destroyed by acid in the stomach. However, enterically-coated tablets enable the enzyme to pass through the stomach unchanged, and be absorbed in the intestine. Serrapeptase has been sold as an anti-inflammatory for about 30 years in Europe and has also been found to be effective at dissolving non-living tissue and especially internal scarring and lesions.



Instead of taking more and more drugs, people could be rescued from a life of misery by taking serrapeptase and other sensible nutrients. Serrapeptase offers a viable alternative to drugs such as aspirin, Ibuprofen, and NSAIDS, as well as STEROIDS - a boon for those suffering with rheumatoid arthritis and a wide array of other autoimmune diseases that trigger the inflammatory response.



While anti-inflammatory drugs may offer temporary, symptomatic relief from pain, swelling and inflammation, they may also be immunosuppressive and are known to hold dangerous side effects. Serrapeptase, on the other hand, eases pain and swelling and no known side effects or drug interactions.



This enzyme is naturally processed commercially today through fermentation and was discovered in the silkworm intestine. When the silkworm is ready to emerge from its cocoon it produces an enzyme that dissolves that very hard shell so that this delicate little creature can enter into a new world. The discovery of this unique biological phenomenon led researchers to study clinical applications of the SP enzyme in man. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histological studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme.



Clinical studies show that serrapeptase induces fibrinolytic, anti-inflammatory and anti-edemic (prevents swelling and fluid retention) activity in a number of tissues, and that its anti-inflammatory effects are superior to other proteolytic enzymes.



Physicians throughout Europe and Asia have recognized the anti-inflammatory and pain-blocking benefits of this naturally occurring substance and are using it in treatment as an alternative to salicylates, ibuprofen, and other NSAIDs. Unlike these drugs, serrapeptase is a naturally-occurring, physiological agent with no inhibitory effects on prostaglandins and is devoid of gastrointestinal side effects.



Besides reducing inflammation, one of serrapeptase's most profound benefits is reduction of pain, due to its ability to block the release of pain-inducing amines from inflamed tissues. It reduces inflammation in three ways: it breaks down the insoluble protein by-products of blood coagulation known as fibrin; it thins the fluids formed form inflammation and injury as well as facilitating their drainage which speeds the tissue repair process.



Serrapeptase has also proven invaluable in accelerating the healing process for sprained muscles, torn ligaments and other traumatic injuries, leg ulcers, edema as well as post-operative inflammation.



Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms. Serrapeptase can be used to treat arterial blockage in coronary patients. Serrapeptase protects against stroke and is reportedly more effective and quicker than EDTA chelation treatments in removing arterial plaque. Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish.



The mechanisms of action of serrapeptase, at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregates and reduces the viscosity of exudates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that serrapeptase has a modulatory effect on specific acute phase proteins that are involved in the inflammatory process.



It is known that proteases and peptidases are only absorbed in the intestinal area. These enzymes are mobilized directly to the blood and are not easily detectible in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. serrapeptase), such as repression of edema and repression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikrein-kinin system and the complement system, thus modifying the inflammatory response.



This is substantiated by reports of significant reductions in C3 and C4 complement, increases in opsonizing protein and reductions in concentrations of haptoglobulin, which is a scavenger protein that inhibits lysosomal protease.



Conditions Serrapeptase has been known to Help:

Pain of any kind

Arthritis

Back Problems, Lower

Back Problems, Neck

Diabetes

Leg Ulcers

Osteoporosis

Polymyalgia Rheumatica

Prostate Problems

Repetitive Strain (RSI) Carpal Tunnel etc

Rheumatoid Arthritis

Inflammation of any kind including -

Breast Engorgement

Cystitis joints or muscles

Fibromyalgia

Fibrocystic Breast Disease

Headaches & Migraines caused by inflammation

Inflammatory bowel diseases (Ulcerative Colitis, Crohn’s, IBS) Lupus



Lung & Chest Problems

Asbestosis, Miners and Farmers Lung, Bronchiectasis

Bronchial Asthma

Bronchitis

Coughs

Cystic Fibrosis

Emphysema

Pulmonary Tuberculosis

Eye Problems

General Inflammation

Blocked veins

Damaged Nerves

Multiple Sclerosis

Ear, Nose & Throat problems

Chronic ear infections

Catarrhal Rhinopharyngitis

Hayfever

Swollen Glands

Sore Throat

Laryngitis

Runny nose

Rhinitis

Sinusitis problems



Trauma Related Issues -

Sports Injuries, prevention & Recovery

Post Operative & Traumatic Swelling

Post Operative Scars & Lesions

Vascular Problems and Misc. -

Varicose Veins & Thrombophlebitis

Arterial Disease, Angina, DVT, Blood Clots

Anti-aging

Animal treatment



Circulatory System

Serrapeptase is apparently active in the cleaning of coronary arteries from occluding layers. Serrapeptase is an enzyme produced by serratia bacteria living on silkworms. With this enzyme the worms melt a hole out of the cocoon. Unlike other enzymes in the field of biology, Serrapeptase dissolves ‘dead’ tissue like or fibrinoid layers in the arteries which chemically could be compared to silk.



A special problem in today’s civilized society is occluding processes in the carotid arteries of the neck. Serrapeptase can be used in cases of severe narrowing of the carotid arteries. Often in patients showing severe symptoms due to the narrowing, including amaurosis fugax (intermittent blindness). The therapeutic results are excellent, certainly lifesaving. It is, however, mandatory that the therapy be conducted for a very long time. The first reliable results can be expected after 6-8 months. Even after month 18, after the onset of the therapy, the patients are improving.



Serrapeptase has been found to be an extraordinary substance for safety removing fibrous blockages from coronary arteries, particularly the carotid arteries found in the neck, which supply blood brain. Serrapeptase is a natural enzyme produced by serratia bacteria living in silkworms. Once the silkworm has completed its transformation into a moth, it uses this substance to “melt” a hole in its cocoon, so that it can escape.



The astonishing fact is that, unlike other biological enzymes, Serrapeptase affects only non-living tissue, like the silk cocoon. This is the reason the butterfly is not harmed. For our health purposes, Serrapeptase dissolves only dead tissues such as the old fibrous layers that clog the lining of our arteries and dangerously restrict the flow of blood and oxygen to the brain. Because of this, Serrapeptase is extremely useful in keeping arterial deposits from building up again after angioplasty (a balloon technique used to clear an artery blockage) or coronary bypass surgery has been performed.



Very often, surgeons are reluctant or unable to open partially closed carotid arteries using laser surgery. They fear that resulting debris could be pushed into smaller connecting arteries and result in a stroke and possibly death. In cases of severe arterial narrowing, Serrapeptase is used with excellent, even life-saving results. Many people have shown significant improved blood flow through their previously constricted arteries, as confirmed by ultrasound examination. Unfortunately, orthodox cardiologists do not employ this important method in their practices.



Multiple Sclerosis - MS

The Symptoms can be progressively worsening (in some cases), Blurred Vision, Speech Problems, Fatigue, Muscle Weakness, Poor Co-ordination, Walking Difficulties.



It is caused by a dysfunctional leaky digestive system leading to a dysfunctional auto immune system exacerbated by other factors including a diet with too many starchy foods (breads, pastry, biscuits, breakfast cereals and high starch root vegetables). Also stress, worry, pharmaceutical drugs (Antibiotics, Steroids, Ibuprofen, Aspirin etc.), Toxic inorganic metals such as Mercury, Viral, Bacterial Problems.



The body's own immune system attacks the myelin sheath, destroying patchy areas. This leads to scar tissue forming that in turn blocks or slows the nerve signals.



Serrapeptase helps immensely as it clears out all of the inflammation and dead/scar tissue, restores a healthy digestive system and provides all of the nutrients to repair the damaged tissue. By clearing away this problem tissue, it enables the nerve signal to work unimpeded and possibly the body’s own healing system to replace it with healthy tissue.



There are no studies that we know of using serrapeptase with MS.



The problem with MS is the scar tissue that forms on the damaged myelin sheath. The serrapeptase dissolves this and allows the nerves to start to function. If there is no damaging attack on the myelin sheath at that point then it may start to. There are good remission reports from the users (even with those with non-remissive type). Some clinics also use Curcumin (extract of turmeric) in their arsenal.



Interest in the potential neuroprotective properties of curcumin has risen after studies found very low levels of neurological diseases, such as Alzheimer’s, in elderly Indian populations. Added to this were studies confirming curcumin as a potent anti-inflammatory agent, effective in wound healing.



Just how curcumin might work to thwart the progression of demyelinization remains unclear. But researchers believe it may interrupt the production of IL-12, a protein that plays a key role in signaling immune cells to launch their assault on the myelin sheath. Curcumin stimulates Glutathione to protect the myelin sheath during regeneration.



Important additional factors found in MS patients are a deficiency of unsaturated fatty acids and other essential nutrients. Hundreds of patients have been treated with enzymatic therapy, with good results, not only in Germany or Mexico, but also in many other countries. It is important to remember that these patients also had a full dietary program.



Cystic Breast Disease

Serrapeptase has also been used in the successful treatment of fibrocystic breast disease. In a double-blind study, 70 patients complaining of breast engorgement randomly were divided into a treatment group and a placebo group. Serrapeptase was superior to the placebo for improvement of breast pain, breast swelling and induration (firmness). 85.7 percent of the patients receiving serrapeptase reported moderate to marked improvement. No adverse reactions to serrapeptase were reported and the researchers concluded that "serrapeptase is a safe and effective method for the treatment of breast engorgement."



Serrapeptase and Sinusitis

Due to its inflammatory properties, serrapeptase has been shown in clinical studies to benefit chronic sinusitis sufferers. In this condition, the mucus in patients’ nasal cavities is thickened and hyper-secreted. This thickening causes mucus to be expelled less frequently. Japanese researchers evaluated the effects of serratia peptidase (30 mg/day orally for four weeks) on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serratia peptidase reduced the viscosity of the mucus, improving the elimination of broncho-pulmonary secretions.



Serrapeptase alters the elasticity of mucus without depleting it. In one study, 140 patients with acute or chronic ear, nose and throat pathologies were evaluated with either a placebo or the active serratia peptidase. Patients taking the serrapeptase experienced a significant reduction in severity of pain, amount of secretion, purulence of secretions, difficulty in swallowing, nasal dysphonia, nasal obstruction, anosmia, and body temperature after three to four days and at the end of treatment. Patients suffering from laryngitis, catarrhal rhinopharyngitis and sinusitis who were treated with serrapeptase experienced a significant and rapid improvement of symptoms after 3-4 days. Physicians assessed efficacy of treatment as excellent or good for 97.3 percent of patients treated with serrapeptase compared with only 21.9 percent of those treated with a placebo.



Asthma and Serrapeptase

Asthma is a range of similar lung diseases that can have a variety of causes. It can be life threatening and so has to be taken very seriously.



What causes Asthma?

The medical/pharmaceutical business would have you believe it is genetic/dust mites/pollution etc. that causes it and that you have no other solution other than to stay with the drugs. The alternate view is that un-natural food and lack of nutrients (and friendly bacteria) is mainly to blame. Although it may be that some people have a genetic predisposition to getting Asthma it is not a life sentence and proper corrective actions will keep it clear even in those people.



The common theme with all of these triggers is inflammation. This is borne out with the fact that the drug of choice, steroids, is anti-inflammatory.



Serrapeptase helps immensely as it clears out all of the inflammation, mucus and dead/scar tissue. By clearing away this problem tissue it enables the bodies own healing system to replace it with healthy tissue and better bronchial/lung function as a result.


Serrapeptase

Cancer, the very name alone scares most people. These days man has a vast amount of information on what things cause the disease, how it progresses, it's growth rates vs. age, which forms are faster spreading than others but what we don't posses is the answer as to how to stop it. Other countries have a better handle on fighting the disease than we do and let’s look at one of the reasons why.



Neoplasm's (cancers) are smart and clever. They can hide and grow for a good spell undetected, they don't need oxygen to live (at least 99.9% of them don't), and while you can kill most all of it with special treatments and surgery all it takes is for one cell to survive to have the condition grow back again. Many cancers are hormonally driven, such as testicular cancer in younger men or cancers of the reproductive organs in middle aged and older women. This provides the perfect fuel as during those periods of life certain hormones abound.



Cancer is built to survive. Cancer cells are covered with fibrin (the same stuff scar tissue is made of). Then as the cells grow together to form tumors, these growths themselves are armored with fibrin. This thick protective coating is designed to prevent the bodies' own defenses (i.e. Natural Killer cells, White blood cells or Oxygen) from getting inside the cell or tumor and destroy it. It is this same defense that keeps chemotherapy out of the cells in all but industrial strength doses. (Doses that are just as likely to kill the patient as the cancer). It is this same defense that keeps out whatever natural agent's patients may be using to combat the disease.



Would it not make sense to have something strip away the outer fibrous wall of cancer so that whatever agents we are using as medicine, whether natural or otherwise, can actually get into the cell and do their job? Sure as heck does? That idea has made sense in Europe and Asia for almost 30 years. There docs have been throwing highly fibrinolytic enzymes (scar tissue eating enzymes) both in blends and as solo enzymes at cancers outer coating and getting better results with turning the tide that the folks here in the States. So why has something with a 30 year history of proven worth and clinical application not reached the shores of America yet? Good question.



In truth, there have been attempts to introduce systemic enzymes into cancer therapy here as far back as the 1970's. Dr. William Kelly DDS, had an enzyme-based anti-cancer therapy he used on pancreatic cancer patients. For those not familiar with that form of cancer the survival rate from it was 0. Dr. Kelly had a record of remission with his patients of 80+%. (1). Not possible thought the ivory towers of establishment medicine. Also two major hindrances kept popping up for Dr. Kelly, first he was a dentist not an MD. Secondly it was also not believed here in this country that enzymes could be absorbed orally. That kept many a doc from even looking at Kelly's findings.



So they sent a young medical intern, Dr. Nicholas Gonzalez to investigate Kelly's claims and debunk him. Far from proving him a fraud the young MD found Kelly's treatments worked and his recovery rate was as he said. That did not settle things. The story of Dr. Kelly's persecution, the mysterious death of his wife and his being run out of the country is too long a tale to take up here. His therapy worked.



Concurrent with those events, in Germany and Japan enzymes were being used both singly and in groups by orthodox medical researchers to augment established therapy. It was found that by introducing a strong fibrinolytic enzyme like chymotrypsin or serrapeptase, anti cancer medications penetrated the cancer cell easier. Therefore lower dosages of chemotherapy could be used and high levels of toxicity in the patient could be avoided. Along with that, researchers found that the enzymes seemed to reduce the side effects of the chemotherapy and, definitely reduced the debilitating muscle wasting that chemo therapy produced in it's patients.



In radiation therapy patients, these doctors found that taking systemic enzymes after treatments reduced the fibrosis that grew in the treated organs. Organs treated with radiation become very hard, filled with scar tissue, which restricts the organ and reduces its overall function. The enzymes were found to prevent a good bit of that scaring from occurring and where it had already happened, the enzymes reduced existing fibrosis. The use of orally administered systemic enzymes to aid in the treatment of cancer was embraced by these countries.



After decades of resistance systemic enzyme therapy as an adjunct to overall cancer treatment has finally gained a foothold in America. Holistic and alternative cancer treatment centers are using enzymes to assist in the fight against the disease. Individual oncologists, realizing the clinical advantage posed by these agents, are now introducing them into the toolbox of things one can do against the disease.



Nattokinase: A Potent and Safe Thrombolytic

Nattokinase represents the most exciting new development in the prevention and treatment of cardiovascular related diseases.



There is a low-grade chronic coagulation disorder that is very broad-based throughout the United States, as evidenced by the prevalence of cardiovascular disease. Clotting is a key factor in the evolution of chronic disease. If we can reverse silent, functional clotting problems, we can offer a profound healing tool to patients. With nattokinase, we know how to stop it. Nattokinase, and other fibrinolytic enzymes, helps keep blood optimally flowing more than any other single intervention in use.



First-hand clinical reports from doctors around the country support reveal that by dissolving branched fibrin—which coagulates prior to full clot formation—nattokinase has proven uniquely helpful in a range of disorders in which hypercoagulation is involved. This includes atherosclerosis, infertility, high blood pressure, dysmenorrhea, fibromyalgia, deep vein thrombosis, varicose veins, hemorrhoids, and ischemic strokes. Also it has proved helpful in chronic infections, where the body lays down fibrin in an attempt to seal off harmful pathogens. Nattokinase can be helpful in slowing many age-associated illnesses, since high fibrin levels create local pathology and ischemia, and block nutrient and oxygen delivery in microcirculation.



The enzyme nattokinase offers a completely natural means of helping prevent and dissolve blood clots. It closely resembles plasmin, the body’s own natural clot-dissolver, and actually enhances the body’s production of plasmin.



Nattokinase cleaves fibrin (the protein that helps our body form the ‘mesh’ of a clot from a wound or trauma). It is like our natural plant kingdom source of plasmin, and is the most potent fibrinolytic enzyme of nearly 200 foods studied for their clot-dissolving abilities. It can even outperform our own body: in one remarkable in-vitro study, nattokinase, urokinase and plasmin (all capable of dissolving clots) were placed on a plate of fibrin. A clear halo showed degraded fibrin. The halo around nattokinase was over twice the size of the halo created by the other two enzymes, which our body manufactures. It also more potent than garlic, bromelain or ginseng.



Nattokinase is a multi-dimensional supplement, useful in each of the following conditions:

• Arterial wall thrombi formation with atherosclerosis

• Atherosclerosis

• Coronary artery disease (CAD)—heart attack prevention

• Pulmonary embolism

• Atrial chamber thrombi present in chronic atrial fibrillation

• Thrombi in the eyes—known as vena Centralia retinae acresia

• Diabetes, which often leads to excess platelet aggregation

• Hypertension—a natto-rich diet or nattokinase supplements have been shown to lower blood pressure. The microscopic trauma to a vessel wall under high pressure increases platelet aggregation and the need for blood thinning in the long term management of the prevention of CAD and strokes in the presence of hypertension.

• Peripheral vascular disease—arterial atherosclerosis or venous thrombosis. Nattokinase almost always improves spider veins and varicose veins. Hemorrhoids are improved as well.

• Senile dementia in which there is poor circulation and blood supply or cerebral thrombi formation

• Ischemic stroke—prevention

• Chronic migraine—where platelet aggregation releases vasoactive chemicals implicated in migraines

• Fibromyalgia, CFS and Lyme Disease—where chronic infection produces antibodies that cross-react with endothelial cells, leading to fibrin deposition

• Dysmenorrhea—where excessive clotting causes painful cramping

• Excessively fast clotting times due to platelet aggregation



Nattokinase and Cardiac Disease: A Profound Intervention

Cardiac disease is the single leading cause of death in America. Stroke is the third leading cause. In 2005, nearly 81 million Americans suffered from high blood pressure, coronary heart disease, stroke or heart failure. But functional clotting problems do steady, silent damage long before obvious disease shows itself.



This is where the real treasure of this enzyme lies, and allows practitioners to treat cardiac disease in a way that puts patients at the forefront of preventive medicine. In fact, by breaking down fibrin, increasing blood flow and thus tissue oxygen levels, you are lowering a risk factor that is implicated in almost all chronic disease.



Atherosclerosis is a multidimensional and evolving disease process, one that begins with free radical attack on the lining of the blood vessels. In fact, atherosclerosis is much like wound healing gone awry: an area becomes inflamed and ‘wounded’, and the body brings in fibrin and platelet aggregates to repair the wound. Before pulmonary emboli, heart attacks or strokes occur, patients accumulate small micro-thrombi that are still reversible. These thrombi develop and are maintained by the gradual accumulation of excessive fibrin and by the inability of the body to break down the fibrin strands effectively. Inflamed plaques produce chemicals that slow down our innate clot-dissolving ability.



Micro-embolization is an often-overlooked component of atherosclerosis. It is fibrin that is implicated in many heart attacks, since cardiac arrest usually occurs after a plaque’s cap fractures, causing a blood clot to form over the fracture and block blood flow. Nattokinase is an ideal treatment, therefore, for heart attack patients, ischemic stroke patients, those at risk of pulmonary embolism or deep vein thrombosis—in short, any patient with a clotting problem.



Hypertension is another hallmark of atherosclerosis. Fifty million Americans suffer from hypertension. By the time hypertension manifests, the blood vessel wall is already damaged and thickened by platelet aggregation. Yet the mainstream treatment strategy is simply to lower blood pressure with medications, never considering why the hypertension is occurring in the first place or how to prevent the effects of hypertension from inducing further clotting.



Nattokinase can play a key role in treating hypertension, as well as preventing the long-term sequelae of damaged, inflamed blood vessel walls. Proof of nattokinase’s efficacy in treating high blood pressure comes from a new, randomized, controlled trial published this September in Hypertension. Scientists at Yonsei University in Korea tested 86 individuals aged 20 to 80 whose blood pressure ranged from 130 to 159 mmHg.



Each received either nattokinase at 2000 FU (fibrinolytic units) per capsule daily or a placebo. After eight weeks, those on nattokinase had significantly lower systolic and diastolic blood pressure. The researchers conclude, “These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.”



Why Nattokinase is Unique

Medical science has synthesized various compounds to help thin blood, from aspirin to warfarin, urokinase and streptokinase. Each has their role. Warfarin, for example, blocks factors in the Vitamin K clotting cascade. However, warfarin does not help a patient lower their platelet aggregation or dissolve their fibrinogen or existing clots.



A patient on warfarin is only treating one part of the clotting cascade and dietary Vitamin K toxicity has not been shown to be a significant etiology in cardiovascular disease. These patients with high fibrinogen and persistent platelet aggregation are still a walking time bomb.



Nattokinase is unique in profoundly lowering fibrinogen levels and degrading branched fibrin. It has three different mechanisms of action. It lyses fibrin directly, changes prourokinase to urokinase, and increases tissue plasminogen activator, which increases our own plasmin. At the same time, nattokinase does not actually destroy the fibrinogen molecule, as streptokinase and urokinase do. It is in a unique class of fibrinolytic agents.



We Are Suffering From A Widespread Chronic Coagulation Disorder

Nattokinase lessens excessive coagulation and thus improves circulation, increasing oxygen to tissues. That is one reason disorders such as fibromyalgia, chronic fatigue syndrome, and chronic infections such as Lyme disease and inflammatory bowel disease respond to nattokinase.



These conditions are in part triggered by pathogen-associated fibrin deposition that leads to tissue hypoxia. In chronic infection, antibodies generated in response to pathogens can cross-react with endothelial cells. The pathogens themselves induce an antibody response that is damaging to the endothelium and the capillary bed.



In a milieu of chronic inflammation and infection, fibrin and soluble fibrin are deposited by the body in response to the “wound.” This causes local ischemia and local tissue hypoxia. In fact, taking these conditions as a model, we might describe a new syndrome called chronic coagulation disorder. Most of us over the age of forty probably suffer from this to some degree. Ensuring that our blood is flowing optimally and bringing healing oxygen to every cell is an important preventive measure.



This enzyme like the guards at Buckingham Palace. It stands there stock still and the one thing it responds to is a clot, or specifically fibrin. When fibrin starts to form—immediately, nattokinase goes into action. Coumadin, on the other hand, thins out the blood by poisoning the part of the coagulation system that’s dependent on Vitamin K. Now that’s certainly one way of approaching clots. Another way is fish oil. Studies on Eskimos found they have half the risk of atherosclerosis of anyone anywhere in the world. However, what doesn’t get talked about is the fact that they have a far greater risk of stroke when a blood vessel is weak and bursts and can’t clot at all. Fish oil is basically doing a lube job on the bloodstream.



You can take two tablespoons of fish oil daily—it is not going to stop you from clotting. Then you add in nattokinase to dissolve fibrin. This will offer an effective and safe treatment for coagulation disorders.



So, for anyone who has just had a heart attack and is trying to prevent a recurrence, or just had an ischemic stroke and doesn’t want to suffer another, or for any indication where Coumadin is recommended, run as fast as you can to your nearest natural medicine doctor, someone who really knows what they’re doing, and ask them about fish oil and nattokinase. If you combine the two your odds are exceptionally high that you’ll have an effective answer to hypercoagulation without putting a yourself at risk by poisoning your Vitamin K cascade.



Nattokinase can be used for hypercoagulation states and clotting disorders. People with bone pain report that their pain vanishes when they take nattokinase. Many older women complain of bone pain, but you don’t want to put them on Coumadin and upset their Vitamin K cascade since that helps form a protein in bone. Nattokinase may do the trick. People prescribed Coumadin for atrial fibrillation, and just cannot tolerate it can use nattokinase instead Many have done fabulously with it.



One condition for which nattokinase where proves nearly miraculous is dysmenorrhea. A lot of women who suffer from painful menstrual cycles are helped with a standard naturopathic protocol of hydrotherapy, lifestyle and nutrition changes and botanicals. But about 20% are not helped and they are miserable every month. The pain is caused by excessive clotting and sending clots through the cervix. Nattokinase relieves the pain.



Nattokinase is also very effective in fibromyalgia. Most fibromyalgia patients improve remarkably on nattokinase, with a standard dose of two capsules twice a day. Nattokinase is also beneficial in atrial fibrillation, because of the danger of throwing a clot. Nattokinase is a wonderful supplement. This should be a standard supplement for patients over forty.



When you have a chronic infection, like Lyme Disease, that gives rise to fibromyalgia and chronic fatigue symptoms, you will deposit excess fibrin in your tissues, and that will trigger a secondary immune response. Your body deposits fibrin so that organisms are inhibited from being very mobile. That is both good and bad. They’re not mobile, so they can’t do as much damage, but you also can’t get antimicrobials to them as easily. Ultimately, in order to treat the infection, we want to get deep into the tissues and this is where nattokinase has a powerful role.



People with this condition can start on nattokinase and build up slowly, and once they have reached a peak level and the pathogens are exposed and vulnerable, they can add in the antibacterial, antifungal, or antiviral products.



New Enzyme Complex Isolated From Earthworms Is Potent Fibrinolytic

Lumbrokinase Has Anti-Platelet, Anti-Thrombotic Activity

The earthworm’s antioxidant, immune-boosting, and clot-dissolving “medicine chest” is as powerful as that of any plant and even many pharmaceuticals. Earthworms have managed to survive for millions of years despite the constant threat of extinction by microbial pathogens. If we can begin to understand their remarkable capacities, we might design similar strategies to assist our own survival.



Earthworms could have been the creatures who first demonstrated a functional dichotomy in evolution:

They evolved to be able to clean up the battlefield after having killed foreign invaders. They have cells that look very much like human natural killer cells and neutrophils when examined with cytofluorimetric analysis and microscopy. They hold healing treasures for us all.



Earthworm leukocytes can recognize human cancer cells as foreign and then kill them. Electron microscopy showed the astonishing “cinematography” of earthworm cells becoming incredibly active, throwing out “pseudopodia”, and literally tearing apart cancer cell membranes from a human cell cancer line named K562. Cancer researchers have never once been able to induce cancer in them. They could be irritated only to the point that they formed inflammatory lesions.



As Charles Darwin once wrote, “It may be doubted whether there are many other animals which have played so important a part in the history of the world.”



Leading researchers and doctors have reported on the power of lumbrokinase to:

• dissolve clots and protect against ischemic heart disease and stroke

• lower fibrinogen levels in cancer patients, which is strongly associated in scientific studies with better outcomes, less metastasis, and slower growth of tumors

• dissolve bacterial biofilms present in chronic infections in conditions like autism and Lyme disease, allowing antimicrobials to work effectively

• offer antiplatelet, anti-thrombotic and anti-apoptotic activity, remarkably regulating hypercoagulation



Earthworms: Ancient Medicine, New Science

The last few years have been a busy time for scientists exploring the medicinal treasures of earthworms. Laboratory, animal and clinical human studies have isolated enzymes and compounds that have proven to be potent fibrinolytics. In healthy human volunteers, an enzyme complex isolated from earthworms increased levels of tissue plasminogen activator (t-PA) and consequently, fibrinolytic activity—without harmful side effects. In a study in 2000 the complex was found to be beneficial for ischemic stroke, without increasing the risk of excessive bleeding as other anticoagulants can.



Using spectrofluorimetery and flow cytometry, another study found that this complex has both anti-platelet activity (by reducing calcium release), anti-thrombotic activity (by reducing intercellular adhesion molecule-1) and anti-apoptotic activity (by inhibiting a specific pathway). All these activities, the researchers conclude, were “remarkably regulated.”



Earthworms have a long history in folk medicine—as far back as the 1300’s. In ancient Burma and Laos, smallpox victims bathed in water where earthworms had been soaked. Worms were boiled in water with salt and onions and the broth given to women with postpartum weakness or difficulty nursing. In Iran dried earthworms were prescribed to help treat jaundice, and American Cherokee Indians used earthworm poultices to draw out thorns. According to the most famous ancient Chinese materia medica, earthworms could treat hemiplegia (a condition where half of the body is paralyzed), fever, and blood clots.



Worms produce unique and potent molecules. Earthworms have an immune system powerful enough to destroy other earthworm allografts, xenografts, but never autografts (an autograft is your own body’s graft; allograft is a graft of foreign material from your own species; and a xenograft is a graft from another species, such as a pig heart valve into a human).



Earthworms can kill bacteria and lyse foreign cells; their body fluid contains leukocytes that are as varied as those of many vertebrates. This is in spite of the fact that, unlike us, earthworms have no adaptive immune system, and do not form antibodies.



Earthworms happily crawl and munch their way through garbage teeming with bacteria and fungi, and not only fight off infection but alter that garbage so that their nitrogen and mineral-rich castings transform it into fertile, oxygen-rich soil. And, as practically every curious child knows, you can slice some earthworms and they will regenerate.



In the last few years, a number of the earthworm’s clot-dissolving, lytic and immune-boosting compounds have been isolated and tested in laboratory and clinical studies. In particular, research has focused on clot-dissolving molecules. Fibrinolytic enzymes have been purified and studied from several species of earthworm, including Lumbricus rubellas and Eisenia fetida, and been found to be both potent and safe. This is very good news, since according to a 2008 conference report from the American Society of Hematology, thromboembolism impacts over one million Americans a year and is responsible for more deaths annually than breast cancer, HIV and motor vehicle crashes combined!


The Key to Lumbrokinase: Active Only in the Presence of Fibrin

Lumbrokinase (LK) is a group of six, novel proteolytic enzymes derived from the earthworm Lumbricus rubellas.



In a 1992 study, a crude extract of the worm was shown to have a potent thrombolytic effect. The heat-stable, purified enzymes were first isolated in 1992 by Japanese researchers. The enzymes have potent fibrin-dissolving properties (fibrin is a protein deposited to create a mesh around a wound), decrease fibrinogen (a protein produced by the liver that is involved in the clotting cascade), lower blood viscosity and markedly reduce platelet aggregation.



Recent research suggests that LK may be effective in the treatment and prevention of ischemic heart disease, as well as myocardial infarction, thrombosis of the central vein of the retina, embolism of peripheral veins, and pulmonary embolisms.



One key, remarkable property of lumbrokinase is that, unlike the medications streptokinase and urokinase, it is only active in the presence of fibrin. Though it dissolves fibrinogen and fibrin very specifically, it hardly hydrolyzes other important blood proteins such as plasminogen or albumin. It has the profound advantage of not causing hemorrhage due to excessive fibrinolysis. In fact, its plasminogen activator is remarkably similar to the plasminogen activator in the tissues of other species. Toxicological experiments have found no negative effects of LK on nervous, cardiovascular, respiratory and blood systems of rats, rabbits and dogs.



Long-term animal experiments show no damage to liver or kidney function, no negative influence on embryonic development, and no mutagenic effects in embryonic rats. LK has no negative effects on blood levels of glucose and lipids. And a 2001 study tested one of the six enzymes of LK to determine whether LK does indeed pass into the blood from the intestines while maintaining its biological activity. This research found that approximately 10% of the full-size enzyme could pass through the intestinal epithelium intact and into the blood. This is not surprising; research from The Hebrew University has shown that many peptides can pass intact and biologically active through the intestinal lumen into the blood.



In a laboratory experiment in 1994 from Seoul National University, lumbrokinase (the six enzymes) was extracted from the earthworm. LK was then immobilized onto a polyurethane surface to investigate its antithrombotic activity. Platelets adhered to the surface and then drastically decreased in number, suggesting that LK digested the fibrinogen and inhibited the ability of platelets to stick to the surface. Similar results were found with an experiment on a rabbit shunt in the laboratory; occlusion time was monitored and it was found that on shunts without LK, occlusion time was 32 and 42 minutes, respectively, but those with LK-immobilized polyurethane had an occlusion time of 140 minutes—as much as four times longer.



Such studies show the potential of immobilized-LK surfaces for eventual use in tissue transplantation. In one remarkable 1999 study, Lumbrokinase was tested on LK-immobilized polyurethane valves which were then fitted to total artificial hearts in three healthy lambs. In the control lamb, the valves were untreated; in the second lamb, only valves on the right were treated, and in the third lamb, only valves on the left were treated.



Implants were left in for up to three days. In the control lamb, thrombi were observed in the inlet parts of the valves. In the other two lambs, thrombi formed only on untreated control valves. Similarly, fibrinolytic activity was observed only in treated valves, and the proteolytic activity of the treated valves was three times higher than that of untreated valves.


A Potent Clot-Dissolver

Animal studies have demonstrated that LK is a potent clot-dissolver. A study in rabbits looked at LK’s ability to dissolve an embolism in the pulmonary artery. The embolism was radioactively tagged, and blood radioactivity was tested 30 minutes, one hour, two hours, three hours, and five hours after LK had been administered. Radioactivity increased markedly at three and five hours, indicating that LK had begun to dissolve the embolism and disperse it into the bloodstream. In another study rectal administration of LK reduced the size of a thrombus in the inferior vena cava in rats. And in yet another 1998 study, freeze dried Lumbricus rubellas was given to rats orally, and then plasmin activity in the blood was measured. At half a gram of LK per kilogram of weight a day, the activity doubled; at one gram, it quintupled.



These results suggest that earthworm powder alone is valuable for thrombotic conditions. Finally, grafts treated with LK and inserted into the inferior vena cava of rabbits were compared to those not treated with LK, at five hours, 1, 2 and 4 weeks after implantation of the graft. Non-treated grafts were totally occluded with thrombus only five hours after implantation. LK treated graft were clear one week later, and those treated with a special covalent bonding method were clear four weeks later. Researchers concluded LK has potential antithrombotic effects in vascular prosthesis.



Lumbrokinase may help protect against myocardial ischemia and heart attack. A 2006 study in rats from Harbin Medical University in China induced heart attack in rats by permanently clamping shut the left anterior descending coronary artery. Lumbrokinase decreased the size of the infarct in a dose-dependent manner.



Human Studies Demonstrate Potency and Efficacy

Clinical trials in humans have been equally impressive. Research has found LK safe and effective as a thrombolytic in human volunteers. A hundred and twenty milligrams of freeze-dried earthworm powder was given orally to seven healthy volunteers aged 28-52 years old, three times a day for seventeen days. Blood was withdrawn before the trial to establish a baseline, and then at days 1, 2, 3, 8 , 11 and 17. Fibrin degradation products, tissue plasminogen activator (t-PA) levels and activity were measured in the blood. The t-PA levels gradually increased through the entire experiment. Fibrinolytic activity also increased.



In an even more significant study from Shanghai Medical University in 2000, LK was used in patients who had suffered a stroke. Fifty-one stroke victims were randomly divided into a treatment group and a control group. The Chinese stroke score was used to evaluate the effect of LK. Several measures of blood viscosity were used—prothrombin time, fibrinogen content, tissue plasminogen activator (t-PA) activity, D-dimer level, and more. In the treatment group, t=PA activity and D-dimer level increased, while fibrinogen decreased significantly. Plasmingogen activator inhibitor activity and prothrombin time were unchanged.



Lumbrokinase inhibits the coagulation pathway and activates fibrinolysis by increasing t-PA activity. This suggests that LK is not only beneficial for ischemic stroke, but that doesn't increase the risk of excessive bleeding as anticoagulants can. This stroke study is backed up by a 2008 study from Harbin Medical University in China. Researchers wondered how LK might have an anti-ischemic action in the brain. Using spectrofluorimeter and flow cytometry, they found that LK has both anti-platelet activity (by reducing calcium release), anti-thrombotic activity (by reducing intercellular adhesion molecule-1) and anti-apoptotic activity (by inhibiting a specific pathway). All these activities, the researchers conclude, were “remarkably regulated by LK.”



Future Directions: A New Antimicrobial?

Do earthworms hold other treasures for us? We know that plasmin has been implicated in wound healing, pathogen invasion, cancer invasion and metastasis. Might earthworms like Lumbricus rubellus also have antimicrobial and anti-cancer potential? Preliminary research is intriguing.



Lumbricin I is an antimicrobial peptide that has been isolated from Lumbricus rubellus. It exhibits antimicrobial activity against both Gram negative and Gram positive bacteria as well as fungi, yet without hemolytic activity against human blood cells. Lumbricin I is rich in proline and actually shares characteristics with peptides found in insects and fruit flies.



What about cancer? Earthworms are able to lyse and destroy foreign cells. As mentioned at the beginning, researchers were unable to provoke my earthworms into getting cancer. When earthworms are examined by electron microscopy their fabulous complexity is revealed.



Researchers from Japan, Korea, China and Croatia have been studying how earthworm peptides may inhibit the growth of spontaneous tumors since the 1990’s. One “killer” glycolipoprotein extract called G-90 retards tumor growth in mice. Lombricine, from Lumbricus terrestris, was purified by Japanese researchers in 1991, and was shown to inhibit mammary tumors in mice. Daily subcutaneous injections markedly slowed the growth of tumors.



Lombricine given orally as part of the diet also slowed the growth of tumors, though to a lesser degree than injection. In addition, LK may help degrade and lyse fibrin clots from the venous blood of patients with malignant tumors. We know that cancer patients are at greater risk of clotting disorders, especially during treatment.



According to research, malignant tumors secrete molecules that inhibit plasminogen activators and protect tumors. Earthworm-derived enzymes like LK can combat a tumor’s protective mechanisms, and render it more vulnerable to treatment and to the innate immune system.



The Future of Earthworms as Medicine

We now know that earthworm enzymes and peptides may provide us with novel, potent and safe approaches to the treatment of thrombosis.



Since thrombosis remains the main cause of death in America despite available drugs, the potential of LK is enormous.


Chronic Infection in Autism Spectrum

Dissolve Biofilms with Fibrinolytic Enzymes

There now is a highly successful strategy to treating chronic bacterial infections and biofilms that involves some new insights and relies in part on fibrinolytic enzymes like nattokinase, serrapeptase and lumbrokinase.



Bacteria build biofilms by first aggregating together, and then rapidly weaving this protective web or matrix around them. They build a polymeric matrix. It’s a sticky, gluey, mucus-y goop and it’s got fibrin in it to give it an intact structure. The bacteria recruit fibrinogen to create fibrin as part of that matrix. At that point they can shed their outer membrane, which has the proteins that serve as antigens and as a target of the immune system. They’re very protected. They’re created a way to survive and procreate and hide from the immune system.



They’re protected because they’ve built this matrix but are still alive, still fermenting and metabolizing and leaching toxins into the bloodstream, although they may have a reduced metabolism compared to active, acute infection. Because of the biofilm they can no longer be reached by an anti-infectious agent or even the immune system. And because of the biofilm you may not find evidence of the infection in the fecal matter when you do stool cultures. You can tell from organic acid testing, from the short-chain fatty acids and metabolites the children are excreting, that they carry these infections. Yet when you do a stool culture you don’t find the bugs.



When you began to work at dissolving the biofilms, you find them, but you find something else that is just as fascinating, something nobody thinks about.



The biofilm matrix has a horizontal and a vertical weave. It’s standard knowledge that biofilm bacteria sequester calcium, magnesium and iron to help build that matrix.



Minerals give the biofilm integrity—as if you’re building a wall. You don’t only want bricks, you want cement. To address this, first you use fibrinolytics to help dissolve the fibrin, then you use EDTA to chelate out the minerals. You start getting huge dumps of toxic metals.



The reason points to something that’s huge, whether we’re dealing with autism, lyme disease or multiple sclerosis, lupus or even cancer.



These are all positively charged cations, that’s why EDTA is able to chelate them well. Mercury, and copper, and other heavy metals are also positively charged. Why would the bug preferentially insert calcium or magnesium? It could use any positively charged metal. As you degrade this biofilm matrix and liberate these bugs, not only do the organic acid levels get higher, but the kids start to dump metals into the bowel. The metals and the bugs are both in the gut.



One researcher presented his proton analysis of brain tissue, attempting to verify the presence of mercury in the brains of autistic children, and he couldn’t find it. Yet he still found evidence of activation of the microglia (a type of glial cell that acts as the first, and main, form of active immune defense in the central nervous system) as a consequence of toxic metals. So the reason they couldn’t find the metals is that they are in the biofilm, along with the bugs, in the gut. The biofilm is using toxic metals, along with common minerals, to build the biofilm, that’s why all of a sudden they get these huge dumps of metals on stool tests.


Where To Start

At good starting point in turning this situation around is to start with enzymes like nattokinase, serra peptase, and lumbrokinase, as well as other mucolytic enzymes, to get the best, broad fibrinolytic effect. Researchers believe nattokinase is particularly good at degrading strep biofilms and strep is a very big player in these childrens’ health. When you run strep titers they will be extraordinarily high.



And these children—and certainly some adults as well—will manifest strep as a comorbid infection that has significant implications for neurological function. They will have very OCD type tendencies, and sometimes almost psychotic outbursts. There isn’t a precise, sudden onset with obvious symptoms.



These persons are very young; some are just a few years old. So its recommend they take half a capsule of each, two times a day.



That would be a 50 milligram capsule of nattokinase, one 1500 milligram capsule of Vitalzym, and a 20 milligram capsule of lumbrokinase. First do the enzymes along with EDTA, then thirty minutes later, add in an arsenal of antimicrobials.



Some holistic practitioners use formulations containing berberine, artemisinin, citrus seed extract, black walnut hulls, artemisia herb, echinacea, goldenseal, gentian, tea tree oil, fumitory, gentian, galbanum oil, oregano oil, neem.



Then an hour later you come in with the binding agents to help mop up the debris. You can use chitosan, citrus pectin, a special bicarbonate formula, organic germanium, chlorella and others. Also use buffering agents, such as buffered vitamin C, since when the body is destroying bacteria it becomes acidic.



Minerals must be assessed, and repleted when necessary. You can test blood work, urine, and stool every two months to monitor the process.



Enzymes, EDTA, antimicrobials, binders, and buffering agents. These are like the missing pieces. In some autistic children who are loaded with viruses and infections they often have terribly high levels of copper in their bloodstream and their hair. They are not eliminating. As they get into the thick of the biofilms their copper blows out of their body in the stool, for months and months. They’ve been loaded with copper. With other children, who’ve struggled for ages to get mercury out—out it comes.



This approach will work for any chronic illness in which chronic infection plays a role. Biofilms are a huge missing piece in Lupus, Lyme Disease, Multiple Sclerosis and any autoimmune-type chronic infection.



You have to ask, what compels the immune system to maintain this state of dysfunction, how could an organism perceived by the immune system as foreign survive its presence?



Either something has corrupted the immune system, or the organism has transformed itself in a way that the immune system can’t find it. That’s what the biofilm does. It’s one of the biggest medical issues we’re dealing with today.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Thu Jan 19, 2012 7:54 pm

a Well, I recently started enteric coated serrapeptase, nattokinase, and I've started back again going through the craziness that is random and induced herxheimer reactions.]

Good info!

Just wanted to say that bromelain is also a cheap solution as well... so long as you take them on an empty stomach. I prefer bromelain because it's cheaper. Although, others rotate between them all.

Also, during the very intense herx reaction could also take very high dose Vitamin D supplement for a couple days and the herx reactions will go away. Don't do it though. I personally will take ibuprofen on a very rare occasion instead if I'm at an extreme point to reduce the immune system.


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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  a<r on Thu Jan 19, 2012 9:03 pm

Hey rdkml.

Thanks for reading, there's a lot of info in that quote and I doubt many will take advantage of it but I really put a lot of value in it.

As for the herx reactions the most I'll take is just anti-oxidants, vinegars, soluble fiber, and a T3 here and there. Give or take a couple T3's.

I've read your posts on numerous of the -kinase's, and you seemed underwhelmed, I was curious, did you use the more or less expensive version of the Serrapeptase?

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  a<r on Thu Jan 19, 2012 9:08 pm

I ask because I've tried your alterior recommendation of bromelaine internally at pretty high doses and gotten little benefit like this, and feel that the supplements have to make it pretty much unaltered to the intestines, unharmed by the stomach to really have an impact.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Thu Jan 19, 2012 9:42 pm

aI was curious, did you use the more or less expensive version of the Serrapeptase?

...bromelaine internally at pretty high doses and gotten little benefit like this,

I've used the Doctor's Best Serrapeptase (less expensive) and it didn't work well enough for me to recommend that brand about it. It did work but you had to take like 10 pills at a time. There was another brand of Serrapeptase but it was about 30 dollars for I think 60 pills that worked well. I can try to find it if you need but it does get very expensive. NOW nattokinase worked pretty well. Lumbrokinase from I think nutricology worked well too but that's also very expensive so I only used one bottle. I personally found the best cost to benefit ratio for me was NOW bromelain. Maybe that's why it's sometimes recommend to alternate between them. Maybe some get a benefit more from one type than another type. Then their is also Ecklonia Cava to help as well.

For me personally, blood donation is huge for me. But maybe that's just me.

Others may find a huge benefit with reduction in fat to starve the biofilm. Those with MS or ALS type symptoms appear to have huge biofilm issues. Some people can have such a huge problem with biofilm it's said strings can come out when donating blood. Course these guys are incredibly ill though. All my research really goes towards MS, ALS, Alzheimer's, Lyme, Autism, and similar. and they are all very connected with a biofilm problem and with detox pathways being overloaded and/or faulty. Hair loss just happens to overlap with biofilm problems like the above issues.

Anyhow, the sugar issues you mention just a guess could be due to fungal issues in the body. What happens is if you kill a parasite, it will release mercury, lead and radiation. The mercury suppresses the white blood cells causing fungal issues to surface. Killing the fungal issue can rerelease mercury back in the system though as it's kinda a protective mechanism in a manner of speaking. So if you take antifungals and you herx then you'd want to take sometime to mop up the mercury which stops herx reactions when killing fungal issues like candida in the body. That's usually the most common reason why people crave sugar IMO/IME. Could also be from insulin resistance. If you have insulin resistance then correcting it should make you feel much better... at least according to Dr. Klinghardt.

As you can tell it's kinda a game of dealing with what surfaces. You kill something, then mop up the mess. Only for something different like biofilm needing to be addressed and then you clean up the mess from that as well. All the while the immune system is causing one to herx. In the end, it does go away and then just need to deal with any what most would call permanent issues that may have taken place before the killing and detoxing. And with Eastern medicine or similar energetic healing can help incredibly well in making one feel better and getting over their issue.

hope this helps and good luck to you.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Thu Jan 19, 2012 9:50 pm

By the way, speaking of problems with detox pathways, I've posted only a couple times in the past about HPU/KPU but because of it's extreme importance for some people, it's always a good idea to see if one has a problem here and correct it with very basic and cheap vitamins.

If you google Klinghardt KPU, he's really the only person that has the best info on it. Here is one link http://www.forresthealth.com/kpu-test.html


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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Thu Jan 19, 2012 9:54 pm

Because my posts are long, just wanted to reiterate for others that the above info that A < R posted on biofilm is extremely important!

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  a<r on Thu Jan 19, 2012 10:25 pm

rdkml wrote:
aI was curious, did you use the more or less expensive version of the Serrapeptase?

...bromelaine internally at pretty high doses and gotten little benefit like this,

I've used the Doctor's Best Serrapeptase (less expensive) and it didn't work well enough for me to recommend that brand about it. It did work but you had to take like 10 pills at a time. There was another brand of Serrapeptase but it was about 30 dollars for I think 60 pills that worked well. I can try to find it if you need but it does get very expensive. NOW nattokinase worked pretty well. Lumbrokinase from I think nutricology worked well too but that's also very expensive so I only used one bottle. I personally found the best cost to benefit ratio for me was NOW bromelain. Maybe that's why it's sometimes recommend to alternate between them. Maybe some get a benefit more from one type than another type. Then their is also Ecklonia Cava to help as well.

I remember the other Serrapeptase, SP Zyma or something similar to that name? I really believe that you should throw a couple dollars towards trying the enteric coated, more expensive Doctors Best product, I believe you will have a much better experience. I really wish I had ordered some Ecklonia Cava this time, I wanted to and for the first time in a long time I can work a lot of hours so I have the money for it, I think my mind is still in "poor" mode. I can get the other things listed at the bottom of that article in the therapy though, and may do that with the EDTA as stated with my ND here in Chilliwack.


For me personally, blood donation is huge for me. But maybe that's just me.

Others may find a huge benefit with reduction in fat to starve the biofilm. Those with MS or ALS type symptoms appear to have huge biofilm issues. Some people can have such a huge problem with biofilm it's said strings can come out when donating blood. Course these guys are incredibly ill though. All my research really goes towards MS, ALS, Alzheimer's, Lyme, Autism, and similar. and they are all very connected with a biofilm problem and with detox pathways being overloaded and/or faulty. Hair loss just happens to overlap with biofilm problems like the above issues.

That's crazy, I hadn't heard that ... but I agree with your area of research, it's very intertwined with any metabolic issue. I've gone from vegan, to all (mostly) raw meat and no sugar, to a very blended diet over three years, and I feel best without fat. The only fats that aren't a problem for me and I eat plenty of are from fish and coconut oil.

Anyhow, the sugar issues you mention just a guess could be due to fungal issues in the body. What happens is if you kill a parasite, it will release mercury, lead and radiation. The mercury suppresses the white blood cells causing fungal issues to surface. Killing the fungal issue can rerelease mercury back in the system though as it's kinda a protective mechanism in a manner of speaking. So if you take antifungals and you herx then you'd want to take sometime to mop up the mercury which stops herx reactions when killing fungal issues like candida in the body. That's usually the most common reason why people crave sugar IMO/IME. Could also be from insulin resistance. If you have insulin resistance then correcting it should make you feel much better... at least according to Dr. Klinghardt.

I've thought about this, but really wanted to hear it from others. I feel as if my insulin resistance is going down quite a bit, it's certainly nowhere as bad as it was a couple of years ago at all.


As you can tell it's kinda a game of dealing with what surfaces. You kill something, then mop up the mess. Only for something different like biofilm needing to be addressed and then you clean up the mess from that as well. All the while the immune system is causing one to herx. In the end, it does go away and then just need to deal with any what most would call permanent issues that may have taken place before the killing and detoxing. And with Eastern medicine or similar energetic healing can help incredibly well in making one feel better and getting over their issue.

hope this helps and good luck to you.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  a<r on Thu Jan 19, 2012 10:27 pm

Too tired to reply to any more right now, haha, shovelling then sleep then some more I want to post.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Fri Jan 20, 2012 4:27 am

Yup, good memory. it was SP-Zyme from here http://www.greenwillowtree.com/-strse-626/spzyme,-serrapeptase,-anti-inflammatory,/Detail.bok works much better than Doctor's Best Serrapeptase which was also enteric coated. Although, who knows if it will work as well for you considering how the enzymes might be different for everyone I'm guessing.

While I haven't watched it before, and while it's not news for you or I, it may be news for other people that aren't aware of the importance of biofilm. In the past 80 years, we've essentially gone from acute ailments that kill people quickly to chronic ailments. With chronic ailments, biofilm is extremely important. Here is a trailer from the documentary regarding the importance of biofilm from minor health ailments to life threatening ailments.



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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  CausticSymmetry on Fri Jan 20, 2012 8:31 am

rdkml wrote:Yup, good memory. it was SP-Zyme from here http://www.greenwillowtree.com/-strse-626/spzyme,-serrapeptase,-anti-inflammatory,/Detail.bok works much better than Doctor's Best Serrapeptase which was also enteric coated. Although, who knows if it will work as well for you considering how the enzymes might be different for everyone I'm guessing.

While I haven't watched it before, and while it's not news for you or I, it may be news for other people that aren't aware of the importance of biofilm. In the past 80 years, we've essentially gone from acute ailments that kill people quickly to chronic ailments. With chronic ailments, biofilm is extremely important. Here is a trailer from the documentary regarding the importance of biofilm from minor health ailments to life threatening ailments.



Why still sick the video states.... Usually a dentist or a doctor did something (iatrogenic), and usually in cases in this video there is a metabolic problem (thyroid suppression) and probably pockets of scar tissue, misaligned teeth, etc.

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  zerx on Fri Jan 20, 2012 9:42 am

I finally have a good idea what biofilms are thanks to a video related to the one rdkml posted:

http://www.youtube.com/watch?v=lpI4WCM_9pM

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  9rugrats5 on Fri Jan 20, 2012 4:11 pm

Good videos, both. I'm wondering if bitters and astringent herbs can act as preventive measure.

Okay, I did some quick search on google scholar of the type: biofilm +X
X = triphala, ginger, clove, cinnamon, garlic.

It seems these herbs could have inhibitory effects on biofilms. By the way, I am not even sure the biofilms mentioned in these studies are the kind of biofilms under discussion. I'm pasting links to the studies and a brief conclusion, but I'm not a medical man, so views of knowledgeable readers are appreciated.

http://www.ncbi.nlm.nih.gov/pubmed/20003940
Evaluation of antimicrobial efficacy of herbal alternatives (Triphala and green tea polyphenols), MTAD, and 5% sodium hypochlorite against Enterococcus faecalis biofilm formed on tooth substrate: an in vitro study.
"5% sodium hypochlorite showed maximum antibacterial activity against E. Faecalis biofilm formed on tooth substrate. Triphala, green tea polyphenols and MTAD showed statistically significant antibacterial activity. The use of herbal alternatives as a root canal irrigant might prove to be advantageous considering the several undesirable characteristics of NaOCl."

http://typographicsplus.com/journals/index.php/JIDA/article/view/686
Comparison of Antimicrobial Efficacy of Ginger Extract and 2% Sodium Hypochlorite against Enterococcus faecalis using Agar Diffusion Method
"Within the limitations of this study, ginger extract shows statistically significant activity against Enterococcus faecalis." (ginger extract showed better inhibition than sodium hypochlorite in their tests)

http://www.springerlink.com/content/y8l2568677111185/
Prevention of Candida albicans biofilm by plant oils
"Effective plant oils were assessed using XTT (2, 3-bis [2-Methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5-carboxanilide) reduction assay for biofilm quantification. Four oils eucalyptus, peppermint, ginger grass and clove showed 80.87%, 74.16%, 40.46% and 28.57% biofilm reduction respectively"

http://aem.asm.org/content/70/12/6951.abstract
Colorimetric Method for Identifying Plant Essential Oil Components That Affect Biofilm Formation and Structure
"Viability staining indicated that there was reduced toxicity of the essential oil components to cells in biofilms compared to the toxicity to planktonic cells but revealed morphological damage to E. coli after cinnamaldehyde exposure."

http://aem.asm.org/content/75/21/6850.abstract
Effect of Cinnamon Oil on icaA Expression and Biofilm Formation by Staphylococcus epidermidis
"Cinnamon oil showed antimicrobial activity against both planktonic and biofilm cultures of clinical S. epidermidis strains. There was only a small difference between planktonic and biofilm MICs, ranging from 0.5 to 1% and 1 to 2%, respectively. CLSM images indicated that cinnamon oil is able to detach and kill existing biofilms. Thus, cinnamon oil is an effective antimicrobial agent to combat S. epidermidis biofilms."

http://www.springerlink.com/content/vj4t7n5757435206/
Anticandidal Efficacy of Cinnamon Oil Against Planktonic and Biofilm Cultures of Candida parapsilosis and Candida orthopsilosis
"This study investigated the anticandidal activity of sixteen essential oils on planktonic and biofilm cultures of C. parapsilosis complex. .. The most active essential oil was cinnamon oil (CO), which showed anticandidal activity against C. orthopsilosis and C. parapsilosis in both suspension and biofilm cultures ... CO is a natural anticandidal agent that can be effectively utilised for the control of the yeasts tested."

http://mic.sgmjournals.org/content/151/12/3873.short
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections
"...P. aeruginosa colonizes the lungs by forming biofilm microcolonies throughout the lung. ...The garlic treatment initially provoked a higher degree of inflammation, and significantly improved clearing of the infecting bacteria."

http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2672.2003.02030.x/full
In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation
"In general, antimicrobial agents show poor efficacy against micro-organisms growing as biofilms, in comparison with free-floating bacteria. ... The present study shows that allicin is active in vitro against S. epidermidis and that sub-MICs of allicin may play a role in the prevention of adherence of this bacteria to medical devices."

http://aac.asm.org/content/49/1/473
Effects of Fresh Garlic Extract on Candida albicans Biofilms
"The in vitro activity decreases as the biofilm phenotype develops, as noted previously with traditional antifungal drugs (1). The superior activity at 1 versus 48 h of treatment probably relates to the half-life of FGE at 37°C and would be an important consideration in the development of in vivo uses (6). ... These results appear promising and merit further investigation for determination of the antifungal activity of FGE against C. albicans biofilms."

http://www.springerlink.com/content/r6325q21t33472l0/
In vitro activity of eugenol against Candida albicans biofilms
"Eugenol, the major phenolic component of clove essential oil, possesses potent antifungal activity... These results indicated that eugenol displayed potent activity against C. albicans biofilms in vitro with low cytotoxicity and therefore has potential therapeutic implication for biofilm-associated candidal infections."

hth,
-9r5-

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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  ubraj on Fri Jan 20, 2012 6:39 pm

Thanks for the info 9rugrats5.


For what it's worth, Gigi is very smart and may have some good thoughts here on the best ways to remove biofilm. Note her recommendation of cistus tea. I've never tried it but it's a recommendation from Dr. K and he mentions it being better than EDTA chelation which is a huge statement as EDTA chelation is usually considered the #1 treatment for biofilm. http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/108050?



I don't appear to have much of a problem with biofilm unless I take large quantities of fat or maybe more accurately fat from processed food PUFA's... but I'm not sure yet. With that said, I do use electrical gadgets all the time and may have something to do with keeping biofilm in check based on these studies springshowers posted.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=529182

http://www.pubmedcentral.nih.gov/articlerender.fcgi?&pubmedid=16056027

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=188289


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Re: Serrapeptase & Nattokinase - Herxheimer reactions and Biofilms

Post  9rugrats5 on Fri Jan 20, 2012 7:50 pm

Thank you, jdp, very interesting info.

best,
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