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Blood vessels and hair growth

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Blood vessels and hair growth

Post  Kazbar on Sat Dec 28, 2013 4:25 am

Found this old science article (2001) on the relation between hair growth/health and blood vessels.

http://www.sciencedaily.com/releases/2001/02/010215074636.htm

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Re: Blood vessels and hair growth

Post  shaftless on Sat Dec 28, 2013 2:52 pm

I wonder what the vegf protein is. And if it occurs naturally in nature.

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Re: Blood vessels and hair growth

Post  AS54 on Sat Dec 28, 2013 7:40 pm

Its a protein found in human beings too, just one of many growth factor molecules. This one is interesting because it does suggest that there is some kind of deficiency or signal blockage in the growth factors signaling the cells in the DP. But I'd be interested in a long term observation on these mice, because when you start artificially enhancing growth factor levels, things get dicey. You are playing around with cancer, and without knowing for sure, I'd venture to say this kind of treatment would greatly increase cancer risk. It would have to be tightly controlled and monitored to keep growth factor levels in a narrow band.

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Re: Blood vessels and hair growth

Post  CausticSymmetry on Sat Dec 28, 2013 9:08 pm

Many drugs that have been synthesized to promote VEGF that lead to cancer, which is why many hair loss drugs never survived trials to enter into the market place.

Of course, there are natural ways to help. Without Vitamin D, hair cannot really enter into a higher level.

J Steroid Biochem Mol Biol. 2013 Dec 5;140C:56-62. doi: 10.1016/j.jsbmb.2013.11.017.
Activation of vitamin D receptor promotes VEGF and CuZn-SOD expression in endothelial cells.
Zhong W1, Gu B2, Gu Y2, Groome LJ2, Sun J3, Wang Y4.

Endothelial dysfunction associated with vitamin D deficiency has been linked to many chronic vascular diseases. Vitamin D elicits its bioactive actions by binding to its receptor, vitamin D receptor (VDR), on target cells and organs. In the present study, we investigated the role of VDR in response to 1,25(OH)2D3 stimulation and oxidative stress challenge in endothelial cells. We found that 1,25(OH)2D3 not only induced a dose- and time-dependent increase in VDR expression, but also induced up-regulation of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and KDR), as well as antioxidant CuZn-superoxide dismutase (CuZn-SOD) expression in endothelial cells. We demonstrated that inhibition of VDR by VDR siRNA blocked 1,25(OH)2D3 induced increased VEGF and KDR expression and prevented 1,25(OH)2D3 induced endothelial proliferation/migration. Using CoCl2, a hypoxic mimicking agent, we found that hypoxia/oxidative stress not only reduced CuZn-SOD expression, but also down-regulated VDR expression in endothelial cells, which could be prevented by addition of 1,25(OH)2D3 in culture. These findings are important indicating that VDR expression is inducible in endothelial cells and oxidative stress down-regulates VDR expression in endothelial cells. We conclude that sufficient vitamin D levels and proper VDR expression are fundamental for angiogenic and oxidative defense function in endothelial cells.

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